According to S2e guidelines, glucocorticosteroid therapy should be given for typical optic neuritis:
- In adults: 500-1,000 mg i. v. as infusion or oral methylprednisolone per day for 3-5 days.
- The indication for administration of single doses above 0.5 g should be made critically because of possible hepatotoxicity (liver-damaging effect), at least in patients over 50 years.
- As an adjunctive medication should be given at least in anamnestically known gastric complaints a gastric acid protection, for example, with proton pump inhibitors (proton pump inhibitors, acid blockers).
- Effect of glucocorticosteroid therapy: it usually accelerates improvement in typical optic neuritis, but does not lead to a better functional final result.
