Products
Oxitriptan is not commercially available in many countries.
Structure and properties
Oxitriptan (C11H12N2O3, Mr = 220.2 g/mol) is a 5-hydroxy derivative of the amino acid tryptophan, the precursor of the neurotransmitter serotonin, and is also known as 5-hydroxytryptophan. Serotonin itself is not bioavailable and is therefore administered as a prodrug.
Effects
Oxitriptan (ATC N06AX01) is administered as a precursor to serotonin to increase concentrations of serotonin in the central nervous system.
Indications
Oxitriptan is approved for the treatment of depressive conditions and is usually administered in combination with a tricyclic antidepressant or other psychotropic drug (according to the SmPC). Other indications include sleep disorders, treatment of postanoxic myoclonias, and migraine prophylaxis.
Contraindications
Oxitriptan is contraindicated in severe renal insufficiency, carcinoid syndrome, and systemic inflammatory connective tissue disease. For complete precautions, see the drug label.
Adverse Effects
Possible adverse effects include digestive symptoms such as diarrhea, anorexia, nausea, vomiting.
