Products
No ophthalmic ointments containing oxytetracycline are commercially available in many countries. In Germany, one preparation is available from Jenapharm.
Structure and properties
Oxytetracycline (C22H24N2O9, Mr = 460.4 g/mol) is present in the ointment as oxytetracycline hydrochloride, a yellow, crystalline, hygroscopic powder that is readily soluble in water. The substance is obtained from certain strains of or prepared by other methods.
Effects
Oxytetracycline (ATC S01AA04) has bacteriostatic properties. The effects are due to inhibition of bacterial protein synthesis by binding to the 30S subunit of ribosomes.
Indications
For the treatment of bacterial infections of the anterior segment of the eye.
Dosage
According to the SmPC. The ointment is usually given into the eye three to six times daily. See also under Administering ophthalmic ointments.
Contraindications
- Hypersensitivity
- Tuberculosis of the eye, fungal infections of the eye.
- Pregnancy and lactation
- Children under 8 years
Full precautions can be found in the drug label.
Interactions
Drug-drug interactions may be possible with hormonal contraceptives.
Adverse effects
Possible adverse effects rarely include allergic reactions and photodermatoses. Visual disturbances may occur immediately after administration.
