1st order
- In Paget’s disease causally underlying ductal carcinoma in situ (DCIS) or invasive breast carcinoma, surgical therapy is guided by the standards of the underlying disease (see Therapy of Breast Carcinoma), including excision (surgical removal) of the nipple-areola complex (NAC; nipple-areola complex, MAK)
- In isolated Paget’s disease of the nipple-areola complex (<5%), only complete resection (R0 resection; removal of the tumor in healthy tissue; no tumor tissue is detectable in the resection margin on histopathology) is required. Further adjuvant (“complementary”) therapy measures are not necessary
