In Paget’s carcinoma (synonyms: Dermatitis papillaris maligna; mammary Paget’s disease; Paget’s disease of the nipple; Paget’s cancer, Paget’s disease; cancerous eczema of the breast; ICD-10 C50.9) is a type of malignant neoplasm (malignant neoplasm) of the mammary (breast).
Mammary Paget’s disease (Paget’s disease of the breast) is understood to be a skin manifestation of ductal carcinoma in situ (DCIS) of the major excretory ducts. In up to 50% of cases, there is a coincidence (coincidence in time) with an invasive, usually ductal carcinoma of the breast.
Paget’s carcinoma may rarely also occur extramammary, i.e. outside the breast, as well as genitoanal (in the area of the genital organs and anus) and/or axillary (in the area of the axilla; with involvement of the apocrine sweat glands).
Sex ratio: Women are predominantly affected, but men can also develop Paget’s carcinoma. This is a bowenoid papulosis, outside the breast, usually in the genital, anus (anus) or axillary (armpit) areas.
Prevalence (disease incidence): Paget’s carcinoma occurs in 1.2-2% of breast carcinomas.
Course and prognosis: In mammary Paget’s carcinoma, prognosis depends on the stage, type of underlying breast carcinoma, and metastasis (formation of daughter tumors), if any. In extramammary Paget’s carcinoma, this is surgically removed. Local recurrence (local recurrence of disease) is relatively common with this form.
