Paget’s Disease: Drug Therapy

Therapy goals

• Pain relief
• Reduction of bone remodeling processes

Therapy recommendations

• Analgesia (pain relief) according to WHO staging scheme:
  • Non-opioid analgesic (paracetamol, first-line agent).
  • Low-potency opioid analgesic (e.g., tramadol) + non-opioid analgesic.
  • High-potency opioid analgesic (eg, morphine) + non-opioid analgesic.
• Antiresorptive drugs (drugs that prevent further bone resorption): bisphosphonates; calcitonin (inhibition of osteoclasts/cells that break down bone).
• See also under “Further therapy“.