In Paget’s disease (synonyms: Paget’s disease of bone; osteodystrophia deformans; osteodystrophia deformans of the cranial bone; osteodystrophia fibrosa localisata; osteitis deformans; osteitis deformans of the skull; Paget’s disease; Paget’s disease of bone; Paget’s syndrome; spinal curvature due to osteitis deformans; ICD-10 M88: Osteodystrophia deformans [Paget’s disease]) is a disease of the skeletal system with bone remodeling.
Paget’s disease is the second most common osteopathy (bone disease) after osteoporosis (bone loss).
The disease mainly affects the following localizations:
- Pelvis
- Femur (thigh bone)
- Skull
- Tibia (shin bone)
- Vertebral body of the lumbar spine
Sex ratio: men are more often affected than women.
Frequency peak: with age (beyond the age of 40), the risk of disease increases. The maximum incidence of the disease is at 60 years.
The prevalence (disease incidence) is 3-4% in Western Europe, which is relatively high compared to America or Asia.
Course and prognosis: Paget’s disease is associated with physical limitations. The prognosis depends on the extent of the disease. Sometimes only a limited area of bone is affected. In such cases, the disease usually causes no symptoms. In other cases, rapid bone remodeling occurs. In about 1-5%, a so-called osteosarcoma (malignant (malignant) bone tumor) develops.
