Products
Paragar Emulsion was approved in many countries in 1966. In 2018, its distribution was discontinued and the drug subsequently received a new composition with the active ingredient macrogol 3350 (new: Paragar Macrogol, powder for the preparation of a solution for oral use). Paragol with kerosene oil, for example, can also be used as a similar substitute (see under Paraffin as a Laxative).
Ingredients
The emulsion contained thick kerosene, agar, and phenolphthalein as active ingredients. Excipients included E 210, E 202, and vanillin as a flavoring agent.
Effects
The drug has laxative properties. Kerosene oil softens the intestinal contents and makes them more slippery. Phenolphthalein stimulates the movements of the colon. The agar protects the mucosa and affects the consistency of the intestinal contents.
Indications
For short-term treatment of constipation.
Dosage
According to the professional information. The emulsion must be shaken before use and is usually taken in the evening. Continuous therapy is not indicated.
Contraindications
- Hypersensitivity
- Existing or suspected intestinal obstruction
- Acute abdominal diseases
- Hepatitis
Full precautions can be found in the drug label.
Interactions
Kerosene oil may reduce absorption of fat-soluble drugs and vitamins. Diuretics and glucocorticoids increase potassium loss. With long-term use, this may increase the effect of cardiac glycosides.
Adverse effects
Possible adverse effects include abdominal cramps, flatulence, bloating, and diarrhea. Phenolphthalein may cause a harmless pink or red discoloration of the urine. Especially in the case of improper use (long-term use, overdose), serious side effects such as severe skin reactions and metabolic and electrolyte disturbances may rarely occur. Phenolphthalein has been criticized for its possible carcinogenic properties, see under Phenolphthalein. It should not be used as a laxative today.
