Parasitic Worms (Helminths), Helminthiasis: Complications

The following are the most important diseases or complications that may be contributed to by cestodes (tapeworms):

Cyclophyllidae

  • Weight loss
  • Appendicitis (inflammation of the appendix)

Echinococcus [Echinococcosis]

  • Occlusive icterus – yellowing of the skin caused by obstruction of the bile ducts.
  • Hemoptysis (coughing up blood)
  • Allergic shock

Pseudophyllidae

The following are the main diseases or complications that can be caused by nematodes (threadworms) with:

Ancylostomatidae

Anisakis

  • Chronic spontaneous urticaria – persistent wheal formation or angioedema (acute onset, painless edema (swelling) of the subcutis (lower layer of the skin) or submucosa (layer of tissue between the mucosa and the muscle layer); or even a combination of both) lasting longer than six weeks; cause is not always known
  • Gastric perforation with peritonitis (peritonitis).
  • Ileus (intestinal obstruction)
  • Allergic reactions

Angiostrongylidae

Ascarididae (roundworms)

  • Ileus (intestinal obstruction)
  • Bronchitis (inflammation of the bronchi)
  • Blindness (amaurosis)

Enterobius

  • Failure to thrive/behave
  • Inflammation of the genital organs, unspecified
  • Appendicitis (inflammation of the appendix)
  • Intestinal perforation (intestinal perforation)
  • Peritonitis (inflammation of the peritoneum)

Filiariidae (nematode)

Rhabditidae

  • Pneumonia (pneumonia)
  • Chronic bronchitis
  • Wasting syndrome

Spiruridae

  • Ulceration (ulceration)
  • Bacterial superinfection of the ulcer

Toxocara canis/-cati

  • Chronic spontaneous urticaria – persistent wheal formation or angioedema (acute onset, painless edema (swelling) of the subcutis (lower layer of the skin) or submucosa (layer of tissue between the mucosa and the muscle layer); or a combination of both) lasting longer than six weeks; cause is not always known
  • Visual acuity loss (loss of visual acuity).
  • Localization in the muscles, liver, lungs or central nervous system is possible

Trichinella (trichinosis) [trichinellosis].

  • Myocarditis (inflammation of the heart muscle)
  • Pneumonia (inflammation of the lungs)
  • Meningitis/encephalitis (brain (skin) inflammation)
  • Rheumatoid complaints

Trichuridae (whipworms)

  • Failure to thrive
  • Anemia (anemia)

The following are the main diseases or complications that can be caused by trematodes (sucking worms) with:

Intestinal fluke

  • Hemorrhages (bleeding).
  • Mucosal ulcerations (ulcers of the mucous membrane)
  • Facial edema
  • Ascites (abdominal dropsy)
  • Cachexia
  • Malabsorption syndrome
  • Ileus (intestinal obstruction)

Liver fluke

  • Cholecystitis (inflammation of the gallbladder)
  • Hepatitis (inflammation of the liver)
  • Cirrhosis of the liver (“shrunken liver”; represents far advanced stage of long-standing liver disease).
  • Malignant neoplasms in the area of liver / biliary tract.

Paragonimus (lung fluke)

  • Pleurisy (pleurisy) with effusion.
  • Pneumonia (inflammation of the lungs)
  • Bronchiectasis (synonym: bronchiectasis) – persistent irreversible saccular or cylindrical dilatation of the bronchi (medium-sized airways), which may be congenital or acquired; symptoms: chronic cough with “mouthful expectoration” (large-volume triple-layered sputum: foam, mucus, and pus), fatigue, weight loss, and decreased exercise capacity
  • Lung abscess – encapsulated accumulation of pus in the lungs.
  • Encephalitis (inflammation of the brain)
  • Meningitis (meningitis)
  • Epileptic seizures
  • Spastic paraplegia – paralysis of all extremities.
  • Affection of the heart, unspecified
  • Subcutaneous granulomas

Schistosoma [schistosomiasis; bilharzia]

  • Bronchitis (inflammation of the bronchi)
  • Acute hepatitis (inflammation of the liver)
  • Granulomatous growths, especially on the liver, urinary bladder and rectum.
  • Recurrent urinary tract infections
  • Carcinoma of the urinary bladder (bladder cancer)
  • Extrauterine pregnancy – pregnancy that settles outside the uterus (womb).
  • Infertility (infertility).
  • Anemia (anemia)
  • Portal hypertension

Possible other sequelae/complications:

  • Cor pulmonale – dilatation (widening) and/or hypertrophy (enlargement) of the right ventricle (main chamber) of the heart due to pulmonary hypertension (increase in pressure in the pulmonary circulation: pulmonary arterial mean pressure (mPAP) > 25 mmHg at rest – normal mPAP is 14 ± 3 and does not exceed 20 mmHG), which may be due to various diseases of the lung
  • Katayama fever – immune response to acute schistosomiasis infection; ca. 2-8 weeks after infection, pulmonary passage of the parasites causes an allergic reaction with edema, wheal formation, and a rapid rise in fever with chills, headache, and cough; due to the deposition of antigen-antibody complexes may develop hepatosplenomegaly (liver and spleen enlargement), lymphadenopathies (lymph node enlargement), sometimes glomerulonephritis (kidney disease caused by inflammation of the renal corpuscles); typically, a pronounced eosinophilia (increase in the number of eosinophilic granulocytes in the blood count)
  • Pulmonary hypertension (portal hypertension; pulmonary hypertension).