Penfluridol

Products

Penfluridol is no longer available as a drug in many countries. Semap tablets are out of commerce.

Structure and properties

Penfluridol (C28H27ClF5NO, Mr = 523.96 g/mol) is a diphenylbutylpiperidine.

Effects

Penfluridol (ATC N05AG03) is potent antidopaminergic, antiemetic, and potent antipsychotic against hallucinations and delusions. It has minimal activity at the 5-HT2 receptor (antiserotonergic) and at the α1 receptor. It has a long half-life and a long duration of action.

Indications

Chronically psychotic patients predominantly with clinical pictures of the schizophrenic type.