Therapeutic target
- Survival benefit or longer disease-free survival.
Therapy recommendations
- Stage pN1 (metastases/daughter tumors in one or two inguinal lymph nodes/groin lymph nodes): Chemotherapy as neoadjuvant and/or adjuvant use with taxane-containing chemotherapeutic agents (paclitaxel/cisplatin/5-FU); complete remissions (i.e., tumor is no longer detectable) are possible
- Fxed/exulcerated inguinal lymph nodes (inguinal lymph nodes with tumor-like change): neoadjuvant chemotherapy (NACT), ie, chemotherapy before surgery, to reduce tumor mass; chemotherapeutic agents: Paclitaxel, cisplatin, 5-fluorouracil.
- Stage ≥ pN2: adjuvant chemotherapy; significant prognostic improvement.
- Systemic metastasis: palliative therapy with CMB regimen (CMB: cisplatin, methotrexate, bleomycin)Note: There is no known second-line therapy with efficacy for penile carcinoma.
Notice:
- Radical lymphadenectomy (lymph node removal) with adjuvant chemotherapy is potentially curative therapy in cases of limited lymph node metastasis (metastasis) of cancer cells to the lymph nodes.
- Penile carcinoma is only moderately chemotherapy sensitive, and response is often partial and short-lived.
