Pfeiffer’s Glandular Fever (Infectious Mononucleosis): Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps:

  • General physical examination – including blood pressure, pulse, body temperature, body weight, body height; further:
    • Inspection (viewing).
      • Skin, mucous membranes and sclerae (white part of the eye), and oropharynx (oral cavity and pharynx)
        • [Enanthem (rash around mucous membranes); morbilliform exanthem (rash) occurring mainly on the arms and trunk of the body; usually papular?
        • Palatal petechiae (fleabite-like bleeding in the area of the palate)?
        • Grayish, greasy imposing coatings?
        • Massively enlarged tonsils?/palatine tonsil]
      • Abdomen (abdomen)
        • Shape of the abdomen?
        • Skin color? Skin texture?
        • Efflorescences (skin changes)?
        • Pulsations? Bowel movements?
        • Visible vessels?
        • Scars? Hernias (fractures)?
    • Inspection and palpation of lymph node stations [lymphadenopathy (lymph node enlargement), especially cervical (“belonging to the neck”) and axillary (belonging to the armpit)]
    • Auscultation (listening) of the heart [due topossible secondary diseases:
      • Myocarditis (inflammation of the heart muscle).
      • Pericarditis (inflammation of the pericardium)
      • Vasculitis (vascular inflammation)]
    • Examination of the lungs (due topossible secondary diseases).
      • Auscultation (listening) of the lungs
      • Bronchophony (checking the transmission of high-frequency sounds; the patient is asked to pronounce the word “66” several times in a pointed voice while the doctor listens to the lungs)[increased sound conduction due to pulmonary infiltration/compaction of lung tissue (e.g., in pneumonia) the consequence is, the number “66” is better understood on the diseased side than on the healthy side; in the case of reduced sound conduction (attenuated or absent: e.g., in pleural effusion). The result is, the number “66” is barely audible to absent over the diseased part of the lung, because the high-frequency sounds are strongly attenuated]
      • Voice fremitus (checking the transmission of low frequencies; the patient is asked to say the word “99” several times in a low voice, while the doctor puts his hands on the chest or back of the patient)[increased sound conduction due to pulmonary infiltration / compaction of lung tissue (eg, in pneumonia) the consequence is, the number “99” is better understood on the diseased side than on the healthy side; in the case of reduced sound conduction (greatly attenuated or absent: in pleural effusion). The consequence is, the number “99” is barely audible to absent over the diseased part of the lung, because the low-frequency sounds are strongly attenuated]
    • Examination of the abdomen (abdomen) [splenomegaly (splenomegaly) ?]
      • Percussion (tapping) of the abdomen.
        • Meteorism (flatulence): hypersonoric tapping sound.
        • Attenuation of tapping sound due to enlarged liver or spleen, tumor, urinary retention?
        • Hepatomegaly (liver enlargement) and/or splenomegaly (spleen enlargement): estimate liver and spleen size.
      • Palpation (palpation) of the abdomen (abdomen) (tenderness?, knocking pain?, coughing pain?, defensive tension?, hernial orifices?, kidney bearing knocking pain?).
  • Cancer screening [due topossible secondary diseases:
    • B-cell lymphoma
    • Burkitt’s lymphoma (endemic in African and Latin American malarial areas and New Guinea) – special type of malignant tumor originating from the lymphatic system.
    • Hodgkin’s lymphoma (malignant disease; emanates from the lymphatic system).
    • Leiomyosarcoma (malignant tumor that usually originates from hair follicles).
    • Lymphomas of the central nervous system
    • Gastric carcinoma (stomach cancer)
    • Nasopharyngeal carcinoma (malignant nasal tumor).
    • Tonsillar carcinoma (cancer of the palatine tonsils)
    • Thymoma (thymus tumor)
    • T-cell lymphoma (disease belonging to the non-Hodgkin’s lymphomas; these originate in the lymphatic system)]
  • Neurological examination [due tosymptoms:
    • Meningitis (meningitis) – very rare.
    • Myalgia (muscle pain)
    • Neuritis (nerve inflammation)]

    [due topossible secondary diseases:

    • Encephalitis (inflammation of the brain).
    • Meningitis (meningitis)
    • Acute transverse myelitis (diffuse spinal cord inflammation).
    • Facial nerve palsy (paralysis of the facial nerve; this supplies facial muscles, among others).
    • Guillain-Barré syndrome (form of polyradiculitis; this refers to the inflammation of several nerve roots).
    • Peripheral neuritis (inflammation of nerves at peripheral nerves)]

Square brackets [ ] indicate possible pathological (pathological) physical findings.