Products
Phenoxybenzamine is commercially available in the form of capsules (Dibenzyran). The drug is not registered in many countries.
Structure and properties
Phenoxybenzamine (C18H22ClNO, Mr = 303.8 g/mol) is a haloalkylamine.
Effects
Phenoxybenzamine (ATC C04AX02) is an irreversible alpha blocker that inactivates alpha receptors by alkylation. It blocks norepinephrine actions, is vasodilatory, and lowers blood pressure.
Indications
Phenoxybenzamine is used to treat bladder voiding dysfunction and pheochromocytoma.