Pirbuterol

Products

Pirbuterol is available as a drug for inhalation in some countries (e.g., USA, Maxair). The drug is no longer approved in many countries.

Structure and properties

Pirbuterol (C₁₂H₂₀N₂O₃, M_r = 240.3 g/mol) is a pyridine derivative closely related structurally to salbutamol (Ventolin, generics), differing from it only in one nitrogen atom. It is present in drugs as pirbuterol acetate, a racemate and a white crystalline powder that is soluble in water.

Effects

Pirbuterol (ATC R03AC08) has sympathomimetic and bronchodilator (bronchospasmolytic) properties. The effects are due to selective binding to beta2-adrenoceptors.

Indications

For the treatment of bronchial asthma.

Dosage

According to the SmPC. Pirbuterol has a short duration of action of about 5 hours and therefore must be inhaled every 4-6 hours.

Contraindications

For complete precautions, see the drug label.

Adverse effects

The most common possible adverse effects include nervousness, tremor, headache, dizziness, palpable heartbeats, rapid pulse, cough, and nausea.