Pathogenesis (disease development)
The causes of polymyalgia rheumatica (PMR) and giant cell arteritis (RZA) are unknown.
Infections are thought to play a role, in addition to genetic factors such as female sex and polymorphisms in the HLA class II gene.
It has been shown that there is a nonspecific increase in the immune response.
Etiology (Causes)
Biographic Causes
- Genetic burden – polymorphisms in the HLA class II gene.
