Products
Potassium bromide is commercially available in Germany in the form of 850 mg tablets (Dibro-Be Mono). In many countries, apart from alternative medicine preparations, no medicines containing potassium bromide are currently available. The drugs can be imported or possibly prepared as an extemporaneous formulation. Kalium bromatum is the Schüssler salt no. 14.
Structure and properties
Potassium bromide (KBr, Mr = 119.0 g/mol) exists as colorless crystals or as a white crystalline powder with a pungent bitter taste that is readily soluble in water.
Effects
Potassium bromide (ATC N03AX21) is antiepileptic, sedative, and increases seizure threshold. These properties may be due to stabilization of nerve cell membranes and are mediated by the bromide.
Indications
Primary and secondary generalized tonic-clonic seizures in early grand mal epilepsy and severe myoclonic syndromes in childhood. As a 2nd-line agent. Potassium bromide is also used as a veterinary drug. Technically, potassium bromide is used, for example, in photography and to produce single crystals in IR spectroscopy (potassium bromide pressing).
Dosage
According to the professional information. The dose is adjusted individually. The narrow therapeutic range must be observed. Tablets are administered 2-3 times daily after meals with sufficient liquid.
Contraindications
Potassium bromide is contraindicated in hypersensitivity, bromide intolerance, renal insufficiency, during pregnancy and lactation, bronchial asthma, and nutritional disorders. For complete precautions, see the drug label.
Interactions
Drug-drug interactions have been described with sedatives and diuretics.
Adverse effects
Potassium bromide triggers a slowing of central nervous processes and may cause fatigue, motor disturbances, and impaired concentration, among other effects. It increases glandular secretions, which can cause mucus, rhinitis, bronchitis, and sinusitis. Further, digestive disorders and very often skin lesions (bromacne) are observed. In case of overdose, poisoning is possible.
