Products
Povidone K 25 is commercially available in the form of eye drops in dropper bottles and as monodoses (Oculac, Protagent). It has been approved in many countries since 1990.
Structure and properties
Povidone consists of linear polymers of 1-ethenylpyrollidin-2-one. The different types of povidone are characterized by the viscosity of their solutions, expressed by the K value. Povidone exists as a white to yellowish-white powder or flake and is readily soluble in water. See under povidone.
Effects
Povidone K 25 (ATC S01XA20) forms a protective tear film on the eye. It relieves the discomfort of dry eyes and has an anti-irritant effect.
Indications
For symptomatic treatment of dry eyes. The monodoses can also be used for wetting contact lenses. Other possible indications include ocular irritation and conjunctivitis (off-label).
Dosage
According to the package insert. The drops are usually placed in the eyes up to five times daily. See also under Administering eye drops. The solution in the vials is preserved with benzalkonium chloride and has a shelf life of one month after opening. The monodoses are not preserved and must be used immediately after opening.
Contraindications
Povidone K 25 is contraindicated in cases of hypersensitivity. Refer to the drug label for complete precautions.
Interactions
Drug-drug interactions are not known. Other ophthalmic agents should be applied at least 15 minutes apart.
Adverse effects
Possible adverse effects include a temporary burning sensation, a sticky sensation, blurred vision, and rarely irritation and hypersensitivity reactions. The preservative benzalkonium chloride may cause irritation to the eye and may cause corneal damage with prolonged use. Therefore, for prolonged use, the unpreserved monodoses should be applied.
