Products
Numerous drugs are available in the form of prefilled syringes. These include, for example, low-molecular-weight heparins, epoetins, methotrexate, TNF-alpha inhibitors, and vaccines. Many, but not all, must be stored in the refrigerator. These should not be frozen. Prefilled syringes should be stored in the package to protect them from light.
Structure and properties
Prefilled syringes are medicines that are prefilled with an injection solution or suspension. This is in contrast to traditional syringes, whose contents are taken from a vial or ampoule, for example. They often contain biologics, but can also contain low-molecular-weight active ingredients such as methotrexate. Because they are already ready to use, the number of steps is reduced, ease of use is increased, and mistakes in drawing up can be avoided.
Areas of application
Prefilled syringes are administered for many different indications. These include, for example (selection):
- Rheumatoid arthritis
- Psoriasis (psoriasis)
- Multiple sclerosis
- Prevention and treatment of thromboembolic diseases.
- Prevention of infectious diseases (vaccines).
- Anemia (anemia)
- Inflammatory bowel disease
- Psychiatric disorders
- Osteoporosis
Dosage
According to the expert information and package insert. Depending on the active ingredient, prefilled syringes are typically administered subcutaneously or intramuscularly and less frequently intravenously. Products requiring refrigeration should be removed from the refrigerator in advance and injected when they have reached room temperature. At room temperature, they are usually stable for only a few hours. Before injection, the skin site should be disinfected with an alcohol swab. Prefilled syringes are used once, as they are not preserved. Used syringes are placed in a syringe disposal box and disposed of at a pharmacy. The injection is administered either by a healthcare professional, nurse, or by the patients themselves. In order for patients to inject themselves, they or their relatives must be adequately instructed by the healthcare professional. Material for injection:
- Sterile alcohol swabs
- Sterile swabs if needed
- Small sterile plaster
- Disposal box
- If necessary, injection needle (usually enclosed).
Adverse effects
Adverse effects depend on the active ingredient. Prefilled syringes can cause puncture injuries. Therefore, some are equipped with a needle protection system that encloses the needle after injection.
