Symptoms of premenstrual syndrome may also occur during premenopause or perimenopause and menopause (menopause) or in association with thyroid disease.Laboratory tests are necessary to rule out other causes of your problems and to make a definite diagnosis.1st order laboratory parameters – obligatory laboratory testsHormone status – cycle diagnostics.
- 17-beta estradiol*
- Progesterone
- Sex hormone-binding globulin (SHBG)* – a specific transport protein for sex hormones, especially testosterone and estradiol.
- TSH (thyroid-stimulating hormone).
- Prolactin
* Studies of hormone levels in women with premenstrual dysphoric disorder (PMDS) demonstrated a consistently elevated level of SHBG leading to decreased free estradiol in the luteal phase.
2nd-order laboratory parameters-depending on the results of the history, physical examination, etc.-for differential diagnostic workup
- FSH (follicle-stimulating hormone).
- Testosterone
- Advanced thyroid diagnostics
- FT3 (triiodothyronine), thyroxine-binding globulin (TBG).
- Thyroid antibodies – thyroid peroxidase antibody (TPO-Ak), thyroglobulin antibody (TAK), TSH receptor antibody (TRAK).
Further thyroid diagnostics are used to detect or exclude hypothyroidism (hypothyroidism) as the cause of the symptoms.Hypothyroidism leads to hyperprolactinemia (increase in prolactin levels) and this in turn (in the fertile phase of life) to a follicle maturation disorder (egg maturation disorder) resulting in estrogen-progesterone imbalance.
