Proguanil

Products

Proguanil is commercially available in the form of film-coated tablets and exclusively as a fixed combination with atovaquone (Malarone, generic). It has been approved in many countries since 1997. Generics went on sale in 2013.

Structure and properties

Proguanil (C₁₁H₁₆ClN₅, M_r = 253.7 g/mol) is an active ingredient of the biguanide group. It exists as proguanil hydrochloride, a white crystalline powder that is practically insoluble in water.

Effects

Proguanil (ATC P01BB01) has antiparasitic properties.

Indications

For the prevention and treatment of malaria.