Pyriprole

Products

Pyriprol is commercially available as a drop-on (spot-on) solution. It has been approved in many countries since 2007.

Structure and properties

Pyriprole (C18H10Cl2F5N5S, Mr = 494.3 g/mol) is a chlorinated and fluorinated phenylpyrazole derivative. It is structurally related to fipronil (Frontline) and is reported to be less toxic than the older compound.

Effects

Pyriprole (ATCvet QP53AX26) has insecticidal and acaricidal properties. The effects are due to binding to GABA receptors and blocking chloride ion transfer. This leads to hyperexcitation and death in fleas and ticks. Pyriprol disperses into the hair coat of the animals after administration and is effective for up to 4 weeks. It acts externally and not through the bloodstream such as lufenuron (Program). It should be noted that the parasites do not fall off immediately, but delayed after 1-2 days.

Indications

For prevention and treatment of flea or tick infestation and allergic flea dermatitis in dogs.

Dosage

According to the package insert. Pyriprol is applied directly to the skin on the back of the animals. Dosage is based on body weight.

  • Do not shampoo or bathe dogs 48 hours before and 24 after treatment.
  • Weekly immersion in water is possible.

Contraindications

Pyriprol should not be used in animals that are too young or light, sick, convalescent, hypersensitive, or in rabbits. Use in cats is also not indicated. Refer to the drug label for complete precautions.

Interactions

Drug-drug interactions are not known.

Adverse effects

Possible adverse effects include local reactions such as greasy or sticky appearance of the hair, hair loss, discoloration of the coat, and itching. Accidental licking may result in increased salivation.