Therapeutic target
- Elimination of the pathogens
- Avoidance of complications
Therapy recommendations
Antibiosis (antibiotic therapy); active substance and duration of therapy depending on the situation:
- Acute infection: first-line agent is doxycycline (tetracycline).
- chronic infection:
- One-year combination therapy with doxycycline and a quinolone (group 3 and 4) or rifampicin.
- Alternative one-year combination therapy: doxycycline and hydroxychloroquine (antimalarials).
- Persons at risk (persons with heart defects, persons with prosthetic heart valves): doxycycline (tetracyclines) and hydroxychloroquine (antimalarials).
- Persons at risk (pregnant women):trimethoprim and sulfamethoxazole (cotrimoxazole).
