Restless Legs Syndrome: Or something else? Differential Diagnosis

Blood-forming organs-immune system (D50-D90).

Endocrine, nutritional, and metabolic diseases (E00-E90).

  • B12 deficiency*
  • Folic acid deficiency*

Cardiovascular system (I00-I99)

Mouth, esophagus (esophagus), stomach, and intestines (K00-K67; K90-K93).

Musculoskeletal system and connective tissue (M00-M99).

  • Myalgia (muscle pain)
  • Rheumatoid arthritis* (inflammation of the joints)

Psyche – nervous system (F00-F99; G00-G99)

  • Akathisia – sitting restlessness; predominantly a side effect of neuroleptics (nerve depressants).
  • Sleep onset myoclonia – twitching of various muscles during half sleep.
  • Migraine
  • Multiple sclerosis (MS)
  • Myelopathies (spinal cord damage)
  • Parkinson’s syndrome
  • Polyneuropathy – disease of the peripheral nervous system.
  • Sleep apnea syndrome – cessation of breathing during sleep that can cause daytime sleepiness and microsleep.
  • Spinocerebellar ataxia (especially type 3) – gait disturbances due to spinal cord and cerebellar damage.

Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99).

  • Calf cramps

Genitourinary system (N00-N99)

  • Renal insufficiency* (kidney weakness).

* Comorbidities (concomitant diseases).