Pathogenesis (development of disease)
Rheumatic fever refers to a specific infection-induced autoimmune reaction triggered by toxins from serogroup A streptococci.
Etiology (Causes)
Biographic causes
- Genetic burden: The risk of developing rheumatic fever after infection with group A β-hemolytic streptococci is influenced by a gene variant for the immunoglobulin long chain.
Disease-related causes
Respiratory system (J00-J99)
- Tonsillitis (inflammation of the tonsils) caused by A streptococci.
- Pharyngitis (pharyngitis) caused by A-streptococci.
