Pathogenesis (development of disease)
Rotaviruses belong to the Reoviridae family. Seven serogroups can be distinguished (A-G), with rotaviruses of serogroup A being the most important worldwide.
Humans are the main reservoir of the virus. Rotaviruses occurring in domestic and farm animals play only a minor role in human disease. Transmission is fecal-oral by smear infection, but can also occur through contaminated food and water. Rotavirus is highly contagious (highly infectious).
The virus replicates at tips of the intestinal villi, leading to rejection of the upper cell layer. This results in malabsorption and increased secretions.
Etiology (Causes)
Behavioral causes
- Smear infection
- Consumption of contaminated food and water
