Products
Rupatadine is commercially available in tablet and oral solution forms (Rupafin, Urtimed), among others. The drug has not yet been registered in many countries.
Structure and properties
Rupatadine (C26H26ClN3, Mr = 415.96 g/mol) is present in drugs as rupatadine fumarate. It is structurally related to loratadine. Rupatadine is also partially metabolized to desloratadine but is not a prodrug in the strict sense.
Effects
Rupatadine (ATC R06AX28) has antihistamine, mast cell-stabilizing, antiallergic, and PAF-antagonistic properties. The effects are due to dual histamine and PAF (platelet-activating factor) antagonism.
Indications
For symptomatic treatment of allergic diseases:
- Allergic rhinitis
- Urticaria
Dosage
According to the professional information. The tablets are usually taken once a day, regardless of meals.
Contraindications
Rupatadine is contraindicated in case of hypersensitivity. For complete precautions, see the drug label.
Interactions
Rupatadine is a substrate of CYP3A4 and corresponding drug-drug interactions are possible. Interactions with central depressant drugs and alcohol cannot be ruled out. A possible interaction with statins has been reported.
Adverse effects
The most common possible adverse effects include drowsiness, fatigue, headache, fatigue, dizziness, and dry mouth.
