Sarcoidosis: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps:

  • General physical examination – including blood pressure, pulse, body temperature, body weight, body height; further:
    • Inspection (viewing) of the skin, mucous membranes, and sclerae (white part of the eye).
      • [Erythema nodosum (nodular erythema), localization: both extensor sides of the lower leg, on the knee and ankle joints; less commonly on the arms or buttocks
      • Red-brownish papules (from Latin papula “vesicle” or nodule).
      • Lupus pernio (large nodular form of sarcoidosis; extensive, livid infiltration of nose, cheeks, earlobes).
      • Cicatricial sarcoidosis (yellow-brownish changes on scars).
      • Abdomen (abdomen)
        • Shape of the abdomen?
        • Skin color? Skin texture?
        • Efflorescences (skin changes)?
        • Pulsations? Bowel movements?
        • Visible vessels?
        • Scars? Hernias (fractures)]
    • Inspection and palpation (palpation) of the lymph node stations (biopsy/tissue collection if necessary; especially the hilar lymph nodes).
    • Auscultation (listening) of the heart
    • Examination of the lungs
      • Auscultation (listening) of the lungs
      • Bronchophony (checking the conduction of high-frequency sounds; the patient is asked to pronounce the word “66” several times in a pointed voice while the physician listens to the lungs) [increased sound conduction due to pulmonary infiltration/compaction of lung tissue (e.g. e.g. in pneumonia) the consequence is, the number “66” is better understood on the diseased side than on the healthy side; in case of decreased sound conduction (attenuated or absent): e.g. in pleural effusion, pneumothorax, emphysema). The result is, the number “66” is barely audible to absent over the diseased part of the lung, because the high-frequency sounds are strongly attenuated]
      • Percussion (tapping) of the lungs [eg. E.g. hypersonoric tapping sound in bronchial asthma, emphysema; box tone in pneumothorax]
      • Vocal fremitus (testing of low frequency conduction; patient is asked to say the word “99” several times in a low voice while the physician places his hands on the patient’s chest or back) [increased sound conduction due to pulmonary infiltration/compaction of lung tissue (e.g. e.g., pneumonia) the consequence is, the number “99” is better understood on the diseased side than on the healthy side; with decreased sound conduction (attenuated: e.g., atelectasis, pleural rind; severely attenuated or absent: with pleural effusion, pneumothorax, emphysema). The result is, the number “99” is barely audible to absent over the diseased part of the lung, because the low-frequency sounds are strongly attenuated]
    • Examination of the abdomen
      • Percussion of the abdomen/examination of the abdomen by tapping the abdominal wall with the fingers.
        • [Attenuation of tapping sound due to enlarged liver or spleen, tumor, urinary retention?
        • Hepatomegaly (liver enlargement) and/or splenomegaly (spleen enlargement): estimate liver and spleen size]
      • Palpation of the abdomen (tenderness?, tapping pain?, coughing pain?, guarding tension?, hernial orifices?, renal bearing tapping pain?).
  • Ophthalmological examination – if eye involvement is suspected.
  • Dermatological examination – in case of skin involvement
  • Neurological examination – in case of suspected involvement of the central nervous system.
  • Orthopedic examination – in case of joint inflammation.

Square brackets [ ] indicate possible pathological (pathological) physical findings.