Schizophrenia: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests.

  • Small blood count
  • Inflammatory parameters – CRP (C-reactive protein) or ESR (erythrocyte sedimentation rate).
  • Fasting glucose (fasting blood glucose).
  • Thyroid parameters – TSH
  • Liver parameters – alanine aminotransferase (ALT, GPT), aspartate aminotransferase (AST, GOT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (gamma-GT, GGT), alkaline phosphatase, bilirubin.
  • Renal parameters – urea, creatinine.
  • Drug test – to exclude substance-induced psychosis.

Laboratory parameters 2nd order – depending on the results of the history, physical examination, etc. – for differential diagnostic clarification.

  • CSF puncture (collection of cerebrospinal fluid by puncture of the spinal canal) for CSF diagnosis – for clinical risk symptoms that may be indicative of a secondary psychotic disorder:
    • Early and acute onset of psychotic symptomatology.
    • Focal neurologic symptoms (selective neurologic deficits caused by smaller, circumscribed lesions of the central nervous system (CNS)), epileptic seizures
    • Clouding of consciousness (most severe form of qualitative disorder of consciousness).
    • Pronounced cognitive deficits (within three months, with memory impairment as a leading symptom.

    [autoimmune encephalitis: pleocytosis in cerebrospinal fluid.]

  • Electrolytescalcium, chloride, potassium, magnesium, sodium, phosphate.