Selenium Disulfide

Products

Selenium disulfide is commercially available as a shampoo (suspension) in fixed combination with sulfur (ectoselen). It has been approved in many countries since 1952. Selsun has not been marketed since 2019.

Structure and properties

Selenium disulfide (SeS2, Mr = 143.1 g/mol) exists as a yellow-orange to reddish-brown powder that is practically insoluble in water. It is an inorganic compound of the two elements selenium and sulfur. The formal structure is S=Se=S, but other and cyclic compounds also occur.

Effects

Selenium disulfide (ATC D11AC03) has antiseborrheic and antimicrobial (antifungal, fungistatic) properties. It is effective against fungi such as dermatophytes and Malassezia furfur, which are involved in the development of dandruff. Furthermore, it has antiproliferative effects on corneocytes and counteracts increased desquamation of the epidermis.

Indications

  • Dandruff
  • Seborrhea, seborrheic dermatitis
  • Pityriasis versicolor

Dosage

According to the instructions for use. The application depends on the product and the indication. For dandruff therapy, the drug is not used daily, but only once or twice a week. Contact with the eyes and mucous membranes must be avoided. Rings and jewelry must be taken off before application. Silver jewelry may oxidize (blacken) on contact with selenium disuflide. Wash hands thoroughly after each application. The product should not get on clothes.

Contraindications

  • Hypersensitivity
  • Open injuries or acute inflammation of the scalp

Full precautions can be found in the drug label.

Interactions

Selenium disulfide should not be used before bleaching, coloring, or perming hair.

Adverse effects

Possible adverse effects include skin reactions, skin irritation, a rash, itching, hair discoloration, hair loss, contact dermatitis, and hypersensitivity reactions.