Secondary prevention of anaphylaxis
- Epinephrine auto-injector (AAI; epinephrine prefilled syringe); active ingredient: epinephrine hydrochloride (0.36 mg per 0.3 milliliter) = epinephrine (0.3 mg per 0.3 milliliter), i.m. (intramuscular, i.e., into the muscle; outer thigh).
- Adrenaline doses depending on body weight as well as clinical condition and taking into account individual risk factors:
- 15-30 kg body weight (bw): 0.15 mg epinephrine.
- 30-60 kg bw: 0.3 mg
- > 60 kg bw: 0.3-0.6 mg
Other notes
- The most common trigger for anaphylaxis (shock resulting from a severe allergic reaction) is food allergy.
- For a recurrence of anaphylactic episode, the probability was particularly high in asthmatics (hazard ratio, HR 1.94) if epinephrine was administered in the care of the first anaphylaxis (HR 2.22) and if the trigger was a food (HR 11.44).
