Side effects
The side effects occur mainly with long-term use of indomethacin. These include:
- Asthmatic complaints (analgesic asthma) due to increased formation of leukotrienes by cyclooxygenase, which cause bronchial constriction
- Stomach ulcers due to the loss of the mucous membrane protecting effect of prostaglandins
- Allergic reactions
- Dizziness, fatigue, nausea, loss of appetite
- Headaches
Contraindications
Patients suffering from certain diseases should not take indomethacin or only after consultation with their doctor. This applies to: Indomethacin should not be used during pregnancy and lactation. In children this should only be done on the doctor’s orders.
- Asthma
- Restricted liver function
- Reduced kidney function
- Morbus Parkinson
- Gastric ulcer (stomach ulcer) in the prehistory
- Active bleeding (e.g. gastric ulcer)
- Allergy to NSARs in general
Interactions
With Kortison: With simultaneous income it comes more frequently to stomach ulcers. With blood-thinning medication: There is an increased risk of bleeding. With Ciclospoprin A, Tacrolimus, ACE inhibitors: This increases the risk of kidney damage.
With digoxin, lithium, methotrexate, phenytoin, phenobarbital, antidiabetics, antihypertensives, diuretics (drainage tablets), Probenecid: The drugs influence each other regarding the concentration of the respective drug. This results in either too low or too high concentrations in the blood and thus no effect or toxic concentrations.
- With Kortison: With simultaneous income it comes more frequently to stomach ulcers.
- With blood-thinning medication: There is an increased risk of bleeding.
- With Ciclospoprin A, Tacrolimus, ACE inhibitors: This increases the risk of kidney damage.
- With digoxin, lithium, methotrexate, phenytoin, phenobarbital, antidiabetics, antihypertensives (blood pressure reducers), diuretics (dehydration tablets), Probenecid: The drugs influence each other with regard to the concentration of the respective drug. This results in either too low or too high concentrations in the blood and thus no effect or toxic concentrations.
