Side effects of Lemocin
Hypersensitivity reactions to one of the ingredients of the lozenges occur in rare cases. So far, no overdoses have been reported when taking Lemocin® lozenges. If the three main active components are considered individually, the active ingredient tyrothricin is hardly absorbed after absorption via the mouth.
Cetrimonium can lead to poisoning when taken in large quantities, which can affect the nervous system. Here the symptoms would be similar to those of the arrow poison Curare. These symptoms include, for example, flaccid muscle paralysis or paralysis of the respiratory muscles.
The anaesthetic active ingredient lidocaine is also well absorbed by the body, but is also quickly broken down again. In the case of an overdose, observation is indicated. If symptoms of poisoning occur, as with any poisoning, symptomatic treatment is given to counteract the poison.
Mode of action
Here, the three main active ingredients must be considered individually, as each one acts differently. Tyrothricin is a so-called polypeptide antibiotic. It has a bactericidal effect, i.e. kills bacteria, especially in so-called gram-positive bacteria.These are often involved in inflammation of the mouth and throat.
Among them are for example the staphylococci and streptococci (classes of bacteria). Polypeptide antibiotics exert their effect by damaging the cell membrane. Tyrothricin is produced by the bacterium Bacillus brevis.
The second component, cetrimonuumbromide, is an ammonium compound. It has a disinfecting effect. In higher concentrations it can also kill bacteria.
Lidocaine belongs to the so-called local anesthetics. In the context of inflammations of the mouth and throat, it is used there mainly for local anesthesia of the painful areas. It achieves its pain-inhibiting properties by altering the sodium channels in the nerve fibers that transmit pain. Many other lozenges that are available over the counter in pharmacies have a similar effect, such as Dorithricin ®.
Disassembly
The polypeptide antibiotic tyrothricin is not absorbed and is therefore excreted in the stool. The anesthetic lidocaine is well absorbed and is then subject to a very pronounced so-called first-pass effect during the first passage of blood through the liver. This means that it is converted into an inactive form relatively quickly after absorption into the blood and thus cannot develop its effect throughout the body.
This results in a locally limited effect that only affects a certain area. In this case, it is only the inflamed mouth or throat area that is responsible for the pain. This means that when taking Lemocin® lozenges there is no effect on the whole body.
