The side effects of prednisolone are the result of the described effects, which influence
- The hormone and electrolyte balance
- Skin
- Muscles
- Bones
- Nervous system and
- Psyche
- Gastrointestinal tract
- Circuit
- Immune System
- Blood and
- Eyes
Under prednisolone administration, conceivable side effects on the hormone balance are the development of Cushing’s syndrome with full moon face and trunk obesity. In addition, prednisolone therapy may lead to disorders of the sodium and potassium balance, weight gain, an increase in blood lipids, a disturbance of the sex hormone balance and the development of diabetes mellitus. Prednisolone can cause various changes in the skin: The major side effects on muscles and skeleton include With regard to the nervous system, depression, sleep disorders or psychosis may occur.
Prednisolone side effects on the gastrointestinal tract are manifested as ulcers (ulcers), bleeding and pancreatitis (pancreatitis). The circulatory system can show high blood pressure, an increased risk of arteriosclerosis (hardening of the arteries) and thrombosis when prednisolone is administered. The immune system is inhibited by prednisolone, so that latent infections break out or emerging infections are masked by the lack of immune reaction.
Side effects of prednisolone in the eyes include cataracts and glaucoma.
- Striae rubrae (stretch marks)
- Atrophy (parchment skin)
- Teleangiectasia
- Petechiae (hypodermia of the skin)
- Steroid acne
- Pigmentation disorder.
- Muscular weakness
- Muscle loss (atrophy and
- Osteoporosis.
Prednisolone has been shown to have a variety of interactions with other drugs. The result is either an increased or a decreased effect or side effect of the other drug.
Prednisolone increases the effectiveness of the following drugs: The effectiveness of the following drugs is reduced: Certain dehydrating agents (saluretics) and laxatives (laxatives) in combination with prednisolone lead to an increased excretion of potassium. Estrogens increase the effect of prednisolone, antacids, rifampicin, barbiturates and phenytoin decrease it. Simultaneous administration of ACE inhibitors results in changes in blood count.
- Cardiac glycosides (due to the potassium deficiency that occurs with prednisolone administration)
- NSAIDs (more gastrointestinal bleeding), such as diclofenac or ibuprofen
- Certain muscle relaxants
- Atropine (increase in intraocular pressure)
- Chloroquine and
- Ciclospoprine A(seizures)
- Antidiabetics
- Praziquantel
- Somatropin
- Marcumar
Prednisolone must not be administered in case of hypersensitivity to this substance. Prednisolone is also contraindicated in certain malabsorption disorders (lactase deficiency, hereditary (hereditary) galactose intolerance, glucose-galactose malabsorption). Increased cautiousness in prescribing Prednisolone is required in a number of situations and diseases, which is mostly due to the undesirable side effects of the drug.
These include active viral infections (shingles, chickenpox, herpes, poliomyelitis), bacterial or systemic fungal infections (mycoses). Prednisolone should also be used with caution 8 weeks before or 2 weeks after a live vaccination (e.g. tetanus) or if you have already had tuberculosis, as well as in cases of gastrointestinal ulcers, high blood pressure that is difficult to treat, heart failure (cardiac insufficiency) or diabetes mellitus and severe osteoporosis. If the patient also suffers from cataracts or mental illness, the administration of prednisolone should also be considered.
However, if the patient has ulcerative colitis or diverticulitis of the bowel (inflamed mucous membrane protrusions), which are among the chronic inflammatory bowel diseases, the risk of intestinal perforation increases when prednisolone is administered. Finally, Prednisolon should be used with caution during pregnancy due to possible increased rates of malformation (formation of clefts in the jaw and palate) and during lactation.
