Side effects | The Paracetamol suppository

Side effects

In general, side effects rarely (? 0.01% to <0.1) to very rarely (? 0.01% with individual cases) occur when taking paracetamol according to the recommendations.

In addition to the systemic side effects, specific side effects can also occur when using paracetamol suppositories. When inserting the suppository, the sensitive mucous membrane of the rectum may be injured. To avoid this, the suppository should be inserted carefully.

To ensure that the suppository can be easily inserted and to avoid the above-mentioned injuries, the suppository must be inserted with the side intended for this purpose facing forward. The use of paracetamol in suppositories can also lead to interactions with other drugs.Therefore, you should consult your doctor or pharmacist before taking various drugs in combination. Interactions are possible when paracetamol is combined with drugs to treat gout, with sleeping pills (phenobarbital), with drugs for epilepsy (phenytoin, carbamazepine), drugs for tuberculosis (rifampicin) and many other drugs.

In particular, drugs potentially toxic to the liver can interact with paracetamol. Therefore, medical consultation in advance is essential.

• Certain liver enzymes such as transaminases (rare) may be increased.
• Bronchospasm can occur very rarely, but usually in known asthmatics (analgesic asthma)
• Also very rare are serious changes in the composition of the blood, which can lead to thrombocytopenia (the number of platelets is too low) or agranulocytosis.
• Furthermore, in very rare cases hypersensitivity reactions may occur, these may appear as simple reddening of the skin, but more severe symptoms such as urticaria and anaphylactic shock are also possible. In this case, immediate discontinuation of therapy is mandatory.