Skin Sensitivity Disorders: Or something else? Differential Diagnosis

Blood, hematopoietic organs – immune system (D50-D90).

  • Polycythemia – disorder in which there are too many red blood cells (RBCs) in the blood.

Endocrine, nutritional and metabolic diseases (E00-E90).

Cardiovascular system (I00-I99)

  • Apoplexy (stroke)
  • Ischemic heart disease
  • Peripheral vascular disease (vascular disease), unspecified.

Infectious and parasitic diseases (A00-B99).

  • Helminthiasis (worm disease).
  • Herpes zoster (shingles)
  • Syphilis (lues; venereal disease)

Musculoskeletal system and connective tissue (M00-M99).

Neoplasms – tumor diseases (C00-D48).

  • Brain tumors, unspecified
  • Spinal cord tumors, unspecified
  • Tumors in the area of peripheral nerves, not specified
  • Tumors of the central nervous system, not specified

Psyche – nervous system (F00-F99; G00-G99)

  • Alcohol abuse (alcohol dependence)
  • Anterior spinal artery syndrome – circulatory disturbance of the anterior spinal artery, usually acute or subacute and without antecedents.Symptoms: acute with spinal shock for a period of weeks to months with loss of all function below the lesion (injury), radicular pain, dissociated sensory disturbance (damage to the tractus spinothalamicus or spinothalamic fibers in the anterior commissure with impaired pain and temperature sensation with preserved touch and vibration sensation); initially flaccid, later spastic paresis (paralysis) at the lesion level, trophic disturbances and bladder and rectal dysfunction.
  • Brown-Sequard syndrome – symptom complex occurring in hemiplegic damage to the spinal cord, with dissociated sensory disturbances and muscle paralysis.
  • Diabetic polyneuropathy – disorders of peripheral nerves or parts of nerves secondary to diabetes mellitus.
  • Epilepsy
  • Funicular myelosis (synonym: funicular spinal disease) – demyelinating disease (degeneration of the posterior cord, lateral cord, and a polyneuropathy/diseases of the peripheral nervous system affecting multiple nerves) caused by vitamin B12 deficiency; symptomatology: motor and sensory deficits that may worsen to paraplegia; encephalopathy (pathological conditions of the brain) of varying degrees.
  • Hysteria
  • Sciatica
  • Carpal tunnel syndrome (KTS) – nerve compression syndrome of the forearm due to compression of the median nerve.
  • Compression of spinal cord or peripheral nerves:
      • Spinal cord (root):
        • C6: Pain and hypesthesia (decreased sensitivity of the skin) on radial side of upper and lower arm (“located on the side of the forearm facing the radius/spoke“) to the thumb; biceps tendon reflex weakened, and arm flexor paresis.
        • C7: Pain and hypesthesia on the outside of the upper arm and forearm to fingers 2 and 3; triceps tendon reflex weakened, and arm extensor paresis (arm extensor paralysis).
        • L5: pain and hypesthesia on outer side of lower leg to big toe, and foot elevator and big toe elevator palsy (heel stand difficult or impossible)
        • S1: pain and hypesthesia on the outside of the upper and on the back of the lower leg and outer edge of the foot, foot drop paresis (toe stand difficult or impossible); Achilles tendon reflex (ASR, also triceps surae reflex) weakened
      • Peripheral nerve:
        • Ulnar nerve: hypesthesia (decreased sensitivity of the skin) of the two ulnar fingers and ulnar edge of the hand (“located on the side of the forearm facing the ulna/elbow), paralysis of the small muscles of the hand.
        • N. radialis: hypesthesia on the radial dorsum of the hand and drop hand.
        • Median nerve: common in carpal tunnel syndrome (TKS; nocturnal pain and hypesthesia on the inside of the first three fingers, followed by atrophy of the thumb pad muscles and weakness for thumb opposition (ability of the thumb to be placed opposite the other fingers))
        • Peroneal nerve: forefoot hypesthesia and foot lifter paresis.
  • Migraine with focal neurological symptoms.
  • Multiple sclerosis (MS)
  • Myelitis (inflammation of the spinal cord)
  • Nerve lesions (nerve damage), unspecified.
  • Polyneuropathygeneric term for certain diseases of the peripheral nervous system affecting multiple nerves (primarily small nerves of the arms and legs).
  • Somatoform disorder with hyperventilation.
  • Syringomyelia – destruction of the tissue of the spinal cord due to defective development.
  • Transient ischemic attack (TIA) – sudden disturbance of blood flow to the brain, resulting in neurological disorders that regress within 24 hours
  • Root syndromes – cervical or lumbar root syndrome.

Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99).

  • Tetany – syndrome of neuromuscular hyperexcitability.

Injuries, poisonings and other consequences of external causes (S00-T98).

  • Whiplash injury
  • Paraplegic syndrome
  • Mercury intoxication (mercury poisoning)
  • Injuries to peripheral nerves or the central nervous system.