Sodium Oxybate

Products

Sodium oxybate is commercially available as an oral solution (Xyrem). It has been approved in many countries since 2006.

Structure and properties

Sodium oxybate (C4H7NaO3, Mr = 126.1 g/mol) is the sodium salt of gamma-hydroxybutyric acid GHB.

Effects

Sodium oxybate (ATC N07XX04) sedative, reduces excessive daytime sleepiness and cataplexy in patients with narcolepsy, and modifies sleep architecture by reducing fragmented nighttime sleep.

Indications

For the treatment of narcolepsy (“sleep sickness”) with a brief loss of muscle tone (cataplexy) in adult patients.

Detailed information

See under GHB