Endocrine, nutritional, and metabolic diseases (E00-E90).
- Obesity (overweight)-particularly with android body fat distribution, that is, abdominal, truncal, central body fat (apple type).
- Andropause (menopause of the male)
- Diabetes mellitus – is accompanied by hyperglycemia (hyperglycemia), which inhibits growth hormone production.
- Hemochromatosis (iron storage disease) – genetic disease with autosomal recessive inheritance with increased deposition of iron as a result of increased iron concentration in the blood with tissue damage.
- Hyperthyroidism (hyperthyroidism).
- Hypopituitarism, e.g., due to craniopharyngioma or Sheehan syndrome (= secondary Empty Sella syndrome (SES)).
- Adrenal hyperfunction (cortisol suppresses growth hormone).
- Hyperglycemia – inhibits growth hormone production.
- Hyperinsulinemia
- Deficiency of steroid hormones (adrenal and ovarian steroid hormones), especially androgens (e.g., andropause).
- Menopause (menopause in women)
- Hypertriglyceridemia (serum triglyceride concentration > 200 mg/dl) → increased degradation of triglycerides to free fatty acids (FA) and glycerol – free fatty acids (FFS) suppress (inhibit) growth hormone production.
Liver, gallbladder and bile ducts – Pancreas (pancreas) (K70-K77; K80-K87).
- Liver diseases – steatosis hepatis (fatty liver), hepatic fibrosis, condition after hepatitis.
Psyche – nervous system (F00-F99; G00-G99).
- Sleep disorders
- Stress
Further
- Resistance of the liver to STH, which in turn manifests itself in lowered concentrations of circulating insulin-like growth factor (IGF).
Medication
- Bromocryptine
- Chlorpromazine
- Corticosteroids
- Cyproheptadine
- Ergotamine alkaloids
- Morphine, apomorphine
- Methylxanthines – aminophylline, theophylline
- Methysergide
- Phenoxybenzamine
- Phentolamine
- Reserpine
- Tolazoline