Spine Tumors: Or something else? Differential Diagnosis

Musculoskeletal system and connective tissue (M00-M99).

  • Aneurysmal bone cyst (AKZ) – tumor-like osteolytic lesions (“bone loss”) with dark red to brownish cavities up to 14 cm3 in size.
  • Paget’s disease (osteodystrophia deformans) – bone disease leading to bone remodeling and gradually thickening of several bones, usually the spine, pelvis, extremities or skull.
  • Pathological fracture – spontaneous fracture due to pathological (pathological) processes in the bone; eg, osteoporosis.

Neoplasms – tumor diseases (C00-D48).

  • Malignant (malignant) solid neoplasms such as:
    • Chordoma (slowly and destructively growing tumors of the spine; these develop from remnants of the chorda dorsalis (notochordoa) at the ends of the spine. Main localizations: Base of the skull, Os coccygis/coccyx).
    • Chondrosarcoma
    • Ewing’s sarcoma – predominantly children and adolescents between the ages of 10 and 18; other locations: Humerus (upper arm bone), ribs, femur (thigh bone), and fibula (fibula bone).
    • Fibrosarcoma (synonym: fibroplastic sarcoma).
    • Osteosarcoma – predominantly adolescents and young adults (60% under 25 years); other localizations: metaphyseal in the long tubular bones.
    • Plasmocytoma (multiple myeloma) – systemic disease. It belongs to the non-Hodgkin’s lymphomas of B lymphocytes. Multiple myeloma is associated with malignant (malignant) neoplasm of plasma cells and the formation of paraproteins
    • Giant cell tumor (synonym: tenosynovial giant cell tumors, synovialiomas) – tumor with usually unclear dignity (decisive for the assessment of dignity is the number of abnormal cells and mitoses present in the tumor).
  • Benign (benign) solid neoplasms such as:
    • Eosinophilic granuloma (unifocal or multifocal eosinophilic granuloma is the localized course of histiocytosis X).
    • Fibrodysplasia
    • Hemangioma (blood sponge)
    • Neurofibroma
    • Osteoblastoma
    • Osteoid osteoma
    • Giant cell tumor (see above).
  • Bone metastases (osseous metastases) [probability of skeletal metastases].
    • Bronchial carcinoma (lung cancer) (30-50%).
    • Cervical carcinoma (cervical cancer) (rare).
    • Endometrial carcinoma (cancer of the uterus) (rare).
    • Urinary bladder carcinoma (bladder cancer) (30-50%).
    • Testicular carcinoma (testicular cancer)
    • Colon carcinoma (colon cancer) (10-30%)
    • Hepatocellular carcinoma (8%)
    • Mammary carcinoma (breast cancer) (> 50%)
    • Renal cell carcinoma (kidney cancer) (30-50%)
    • Esophageal carcinoma (esophageal cancer.
    • Ovarian carcinoma (ovarian cancer) (2-8%)
    • Pancreatic carcinoma (cancer of the pancreas) (5-10%)
    • Prostate carcinoma (cancer of the prostate gland) (> 50 %)
    • Thyroid carcinoma ((thyroid cancer) (40%)
  • Leukemia (blood cancer)
  • Lymphoma – malignant neoplasms originating from the lymphatic system.

Injuries, poisonings, and other consequences of external causes (S00-T98).

  • Fracture (fracture of a bone) in the spine.
    • Traumatic condition