Subclinical Inflammation: Complications

The following are the most important diseases or complications that can be caused by subclinical inflammation (silent inflammation):

Respiratory system (J00-J99)

Eyes and eye appendages (H00-H59).

Macular degeneration – degenerative disease of the macula lutea (yellow spot of the retina/retinal).

Endocrine, nutritional and metabolic diseases (E00-E90).

Obesity
Diabetes mellitus type 2 (insulin resistance) (due toproinflammatory immune mediators).
Metabolic syndrome – clinical name for the symptom combination obesity (overweight), hypertension (high blood pressure), elevated fasting glucose (fasting blood sugar) and fasting insulin serum levels (insulin resistance) and dyslipidemia (elevated VLDL triglycerides, lowered HDL cholesterol). Furthermore, a coagulation disorder (increased tendency to clotting), with an increased risk of thromboembolism can often be detected.
Periodontitis – inflammation of the periodontium (periodontium).
Sudden cardiac arrest (PHT; English “Sudden cardiac arrest”, SCA).

Cardiovascular system (I00-I99)

Apoplexy (stroke)
Atherosclerosis (arteriosclerosis; hardening of the arteries)
Cardiovascular diseases (heart and vascular diseases; CVD; engl. cardiovascular disease).
Coronary artery disease (CAD; coronary artery disease).
Myocardial infarction

Liver, gallbladder and bile ducts – Pancreas (pancreas) (K70-K77; K80-K87).

Steatosis hepatis (fatty liver) → steatohepatitis (fatty liver hepatitis).
Non-alcoholic fatty liver diseases (NAFLD) → liver cirrhosis/irreversible damage to the liver and a pronounced remodeling of liver tissue.

Mouth, esophagus (food pipe), stomach, and intestines (K00-K67; K90-K93).

Musculoskeletal system and connective tissue (M00-M99).

Osteoporosis (bone loss) – patients with chronic activation of the inflammasome NLRP3 due to missense mutations (point mutation causing incorporation of a different amino acid into the protein) have a high incidence of osteoporosis
Sarcopenia – age-associated excessive loss of muscle mass and strength and functional decline.

Neoplasms – tumor diseases (C00-D48).

Malignant neoplasms, without further specification (oncogenesis due to chronic inflammation)

Psyche – nervous system (F00-F99; G00-G99).

Further

Aging/age-related morbidity (disease incidence) and mortality (death rate) ↑ [due to”inflamm aging” (inflammaging)]
Immunosenescence – slow deterioration of the immune system in the elderly.
Thymus involution – complete regression of the thymus.