The following are the most important diseases or complications that may be contributed to by testicular malignancies (testicular tumors):
Endocrine, nutritional, and metabolic diseases (E00-E90).
- Hypogonadism (hypofunction of the gonads).
Circulatory system (I00-I99)
- Cardiovascular disease due to acute and long-term toxicities.
Neoplasms and tumor diseases (N00-N99).
- Metastasis (formation of daughter tumors), especially to the following organs:
- Bone
- Liver
- Lungs
- Lymph nodes
- Recurrence (recurrence) of disease (peak incidence: -2 years; late recurrence: ≥ 10-35 years).
- Second tumors (solid tumors; ≥ 10 years after therapy).
Further
- Increased risk of metabolic disorders and cardiovascular disease (direct consequence of treatment or indirectly due to hypogonadism?): patients with hypogonadism showed metabolic syndrome in 36.0% of cases.Conclusion: in patients who show signs of hypogonadism in the post-treatment period, metabolic syndrome laboratory parameters should be determined (e.g., HbA1c; see “Metabolic syndrome/laboratory diagnostics” below).
Psyche – Nervous System (F00-F99; G00-G99).
- Paraneoplastic encephalitis (in men with seminoma, antibody-mediated paraneoplasia occurs;/ egcancer symptoms not primarily due to the neoplasia (neoplasm); autoantigen is “kelch-like protein 11” (KLHL11)).
Genitourinary system (N00-N99).
- Subfertility (fertility limitation).
