Medical history (history of illness) represents an important component in the diagnosis of thrombocytopenia. Family history
- What is the general health of your family members?
- Are there any diseases in your family that are common?
- Are there any hereditary diseases in your family?
Social history
- What is your profession?
- Are you exposed to harmful working substances in your profession?
Current medical history/systemic medical history (somatic and psychological complaints).
- What symptoms have you noticed?
- How long have the symptoms been present?
- Have the skin or mucosal changes occurred acutely? Or have they developed over a longer period of time?
- Where are the skin or mucosal changes located? Are they localized or do they occur all over the body?
- Are the skin or mucosal changes painful?
- Are there any other symptoms? Acute fever* , general feeling of illness?
- Was there a trigger for the symptomatology?
- Do you bruise quickly when you bump?
- Do wounds bleed for a very long time after?
- Have you lost weight unintentionally?
Vegetative anamnesis including nutritional anamnesis.
- Please tell us your body weight (in kg) and height (in cm).
- Do you drink alcohol on a regular basis? If so, what drink or drinks and how many glasses of it per day?
- Do you smoke? If yes, how many cigarettes, cigars or pipes per day?
- Do you use drugs? If yes, what drugs and how often per day or per week?
Self history incl. medication history.
- Previous diseases (blood diseases, tumor diseases).
- Operations
- Radiotherapy
- Vaccination status
- Allergies
- Pregnancies
- Environmental history (benzene?)
Medications that may cause thrombocytopenia or platelet dysfunction:
- Antibiotics [platelet dysfunction.]
- Acylaminopenicillin + ß-lactamase inhibitor (piperacillin + tazobactam, amoxicillin + clavulanic acid, ampicillin + sulbactam).
- Aminopenicillin (amoxicillin, ampicillin).
- Benzylpenicillin (penicillin G)
- Penicillin (piperacillin + tazobactam, penicillin G, penicillin V).
- Staphylococcal penicillins (flucloxacillin).
- Trimethoprim/sulfamethoxazole
- Vancymycin
- Analgesics (diclofenac, ibuprofen, paracetamol).
- Antiarrhythmic drugs (amiodarone)
- Antidiabetic drugs (chlorpropamide)
- Antiepileptic drugs (carbamazepine, phenytoin, valproic acid/valproate).
- Antimalarials (chloroquine)
- Antifungal agents (amphotericin B)
- Antiprotozoal agents
- Analogue of the azo dye trypan blue (suramin).
- Nitroimidazoles (benznidazole)
- Pentamidine
- Antithrombotic agents (heparin group, factor Xa inhibitors/direct thrombin inhibitors).
- Intestinal therapeutics, anti-inflammatory – mesalazine.
- Diuretics (hydrochlorothiazide, HCT).
- Heparin + HIT II (heparin-induced thrombocytopenia) – Argatroban, danaparoid, lepirudin.
- Cardiac glycosides (digoxin).
- Hormones
- Androgen (danazol)
- Antiestrogens (tamoxifen)
- Somatostatin analogue (octreotide).
- Immunomodulator (levamisole)
- Immunosuppressant (thalidomide)
- Janus kinase inhibitors (ruxolitinib).
- Lithium
- Antimalarials (quinine)
- Monoclonal antibodies (abciximab)
- MTOR inhibitors (everolimus, temsirolimus).
- Phosphodiesterase III inhibitors (enoximone, milrinone).
- X-ray contrast agent (diatrizoate).
- Tuberculostatics (rifampicin)
- Antiplatelet agents (TAH): clopidogrel, eptifibatide, tirofiban.
- Antivirals
- Antisense oligonucleotide (fomivirsen).
- Nucleoside analogues (aciclovir , cidofovir, famciclovir, ganciclovir, valganciclovir).
- Protease inhibitors (PI; protease inhibitors) – boceprevir, telaprevir.
- Other (foscarnet)
- Cytokines (interferon alpha (interferon α), interferon α-2a, interferon α-2b, peg-interferon 2α, interferon gamma).
- Cytostatics
* If this question has been answered with “Yes”, an immediate visit to the doctor is required!(data without guarantee)