Products Acarbose is commercially available in tablet form (Glucobay). It is usually combined with other agents such as metformin, insulin, or sulfonylureas to enhance the antidiabetic effect. Acarbose has been approved in many countries since 1986. Structure and properties Acarbose (C25H43NO18, Mr = 645.60 g/mol) is a pseudotetrasaccharide obtained from the bacterium by fermentation. It … Acarbose Effects and Side Effects
Symptoms The possible acute symptoms of type 2 diabetes include: Thirst (polydipsia) and hunger (polyphagia). Increased urination (polyuria). Visual disturbances Weight loss Fatigue, exhaustion, declining performance. Poor wound healing, infectious diseases. Skin lesions, itching Acute complications: Hyperacidity (ketoacidosis), hyperosmolar hyperglycemic syndrome. Untreated diabetes is far from harmless and can lead in the longer term to … Diabetes Mellitus Type 2: Causes and Treatment
Active ingredients Insulins substitute for endogenous insulin: Human insulin Insulin analogues Biguanides reduce hepatic glucose formation: Metformin (Glucophage, generic). Sulfonylureas promote insulin secretion from beta cells: Glibenclamide (Daonil, generic). Glibornuride (Glutril, off label). Gliclazide (Diamicron, generic). Glimepiride (Amaryl, generics) Glinides promote insulin secretion from beta cells: Repaglinide (NovoNorm, generic). Nateglinide (Starlix) Glitazones decrease peripheral insulin … Antidiabetics
Products Pancreatin is commercially available in the form of capsules, dragées, and tablets (Combizym, Creon, Panzytrat). Structure and properties Pancreatin (pancreatic powder) is obtained from the fresh or frozen pancreas of mammals, such as pigs or cattle. The substance contains digestive enzymes with proteolytic, lipolytic and amylolytic activity. Pancreatin is a faint brown, amorphous powder … Pancreatin
Symptoms Gestational diabetes is a glucose intolerance that is first discovered during pregnancy and is common, occurring in approximately 1-14% of all pregnancies. Typical symptoms of diabetes mellitus such as thirst, frequent urination, and fatigue may occur, but are considered rare. Nonspecific complaints such as increased susceptibility to urinary tract infections may indicate gestational diabetes. … Gestational Diabetes
Products Miglitol was commercially available in tablet form (Diastabol). It was approved in many countries in 1997 and went out of commerce in 2011. It is still available in some countries. Acarbose (Glucobay) can be used as a possible alternative. Structure and properties Miglitol (C8H17NO5, Mr = 207.2 g/mol) is an analog of glucose and … Miglitol
Contraindications Glucobay® also has certain contraindications for which the drug must not be taken. These include: A hypersensitivity reaction with previous use of Glucobay® Chronic inflammatory bowel disease (here the risk of a disturbance of absorption in the bowel may be too high) All types of diabetic metabolic derailment with coma ketoacidosis and hypoglycaemia Coma … Contraindications | Glucobay
Acarbose Definition Glucobay® is an antidiabetic and is used for the treatment and comedication of diabetes mellitus type I and II. Mode of action Glucobay® inhibits an enzyme called α-glucosidase, which prevents the rise of blood sugar levels in the body after meals. α-Glucosidase has normally the task in the intestine the multiple sugars to … Glucobay
Effects Alpha-glucosidase inhibitors (ATC A10BF) have antidiabetic properties: Glucose is released more slowly in the gut and absorbed more slowly into the blood Decrease the rise in blood glucose after meals and blood sugar fluctuations. Do not cause hypoglycemia as monotherapy Mechanism of action The action is based on the inhibition of intestinal enzymes (alpha-glucosidases) … Alpha-Glucosidase Inhibitors
Mandibuloacral dysplasia is a congenital malformation syndrome associated with abnormalities of the skeleton that is inherited in an autosomal recessive manner. Two different types of the disease are known, caused by mutations in two different genes. A causative therapy does not yet exist. What is mandibuloacral dysplasia? In medicine, dysplasias are congenital malformations in human … Mandibuloacral Dysplasia: Causes, Symptoms & Treatment
Insulin resistance is a disorder in sugar metabolism. The pancreas must produce more insulin because it is more poorly absorbed by the cells and they are “resistant,” so to speak. What is insulin resistance? Insulin resistance is related to diabetes. It is also known as prediabetes. Diabetes is taking on an increasingly important role in … Insulin Resistance: Causes, Symptoms & Treatment
What are alpha-glucosidase inhibitors and how do they work? The active ingredients from the group of substances known as alpha-glucosidase inhibitors inhibit enzymes in the intestine that break down carbohydrates absorbed with food into glucose. As a result, blood sugar rises only slowly after eating. However, alpha-glucosidase inhibitors have no effect when consuming foods with … Alpha-glucosidase inhibitor
