Psoriatic arthritis is an inflammatory disease of the joints that is usually accompanied by psoriasis. Thus, about 5 to 15 percent of those affected by psoriasis develop this form of arthritis, the underlying cause of which has not yet been determined. What is psoriatic arthritis? Psoriatic arthritis is the name given to an inflammatory disease … Psoriatic Arthritis: Causes, Symptoms & Treatment
Symptoms Rheumatoid arthritis is a chronic, inflammatory and systemic joint disease. It manifests as pain, symmetrically tense, achy, warm, and swollen joints, swelling, and morning stiffness that lasts for more than an hour. Initially, the hands, wrists, and feet are most affected, but later numerous other joints are also affected. Over time, deformities and rheumatoid … Rheumatoid Arthritis Causes and Treatment
Products TNF-α inhibitors are commercially available as injectable and infusion preparations. Infliximab (Remicade) was the first agent from this group to be approved in 1998, and in many countries in 1999. Biosimilars of some representatives are now available. Others will follow in the next few years. This article refers to biologics. Small molecules can also … TNF-Α Inhibitors
Products Adalimumab is commercially available as a solution for injection (Humira). It was approved in the United States in 2002 and in many countries and the EU in 2003. Biosimilars are available in many countries. Structure and properties Adalimumab is a human IgG1 monoclonal antibody against TNF-alpha. It is composed of 1330 amino acids and … Adalimumab Effects and Side Effects
Symptoms Psoriasis is a chronic inflammatory, benign, and noninfectious skin disease. It manifests as symmetrical (bilateral), sharply demarcated, bright red, dry, raised plaques covered by silvery scales. Typically affected areas are the elbows, knees, and scalp. Itching, a burning sensation and pain are other symptoms, and scratching further aggravates the condition. Psoriasis can also affect … Psoriasis Causes and Treatment
Products The first therapeutic monoclonal antibody was approved in 1986. Muromonab-CD3 (Orthoclone OKT3) binds to the CD3 receptor on T cells and has been used in transplantation medicine. Numerous drugs containing antibodies are now available. A selection of active substances can be found at the end of this article. These are expensive drugs. For example, … Monoclonal Antibodies
Products Therapeutic proteins are usually administered in the form of injection and infusion preparations and must be stored in a refrigerator. The first recombinant protein to be approved was human insulin in 1982. Some proteins, for example, are also available in tablet, capsule, and powder form and can be stored at room temperature, such as … Therapeutic Proteins
Adalimumab is a drug substance that binds to tumor necrosis factor-alpha (TNF-alpha), a messenger of the immune system. Under the trade name Humira, adalimumab is used for inflammatory rheumatic diseases. What is adalimumab? Under the trade name Humira, adalimumab is used for inflammatory rheumatic diseases. Adalimumab is a human monoclonal antibody that binds specifically to … Adalimumab: Effects, Uses & Risks
Products Immunosuppressants are commercially available in numerous dosage forms, for example, as creams, ointments, tablets, capsules, solutions, eye drops, and injectables. Structure and properties Within immunosuppressants, several groups can be identified. These include steroids such as the glucocorticoids, substances of microbiological origin such as ciclosporin and mycophenolate mofetil, derivatives of nucleic acids and their components … Immunosuppressants
Cortisone therapy Cortisone is used in Crohn’s disease primarily for the treatment of acute relapses. It can be administered systemically as a tablet or in some cases locally as an enema or klysma. In mild to moderate attacks, cortisone preparations almost always lead to an improvement in symptoms. Even the most severe relapses can be … Cortisone therapy | Medicines for Crohn’s disease
Biologics Biologics (also known as biologicals or biopharmaceuticals) are drugs that are very similar or similar to the body’s own proteins. In the case of Crohn’s disease, for example, antibodies are used that attack very specific cells or even just molecules of the body and thus fight inflammation. Adalimumab and Infliximab, both of which are … Biologics | Medicines for Crohn’s disease
Medicines for joint pain in Crohn’s disease Joint pain is a common side effect of Crohn’s disease. Sometimes the joints are also inflamed (arthritis), but more often there is joint pain without signs of inflammation. In an acute episode, large joints are usually affected, while in remission it is mainly the small joints that cause … Medicines for joint pain in Crohn’s disease | Medicines for Crohn’s disease
