Hydrolase is a group of enzymes that hydrolytically cleaves substrates. Some hydrolases contribute to the normal functioning of the human body, for example, starch-cleaving amylase. Other hydrolases are involved in the development of disease and, like urease, are produced in bacteria. What is hydrolase? Hydrolases are enzymes that use water to cleave substrates. The substrate … Hydrolase: Function & Diseases
Products Oligomannate was approved in China in 2019 in the form of capsules (Shanghai Green Valley Pharmaceuticals). The group led by Prof. Geng Meiyu at the Shanghai Institute of Materia Medica spent more than 20 years on the research. This is the first new oral Alzheimer’s drug since 2003, and another Phase III clinical trial … Oligomannate
Products Gelatin is available as a pure substance in grocery stores and in pharmacies or drugstores. It is found in many processed foods, pharmaceuticals, and sweets, among other products. Structure and properties Gelatin is a purified mixture of proteins obtained by either partial acid, alkaline, or enzymatic hydrolysis of collagen. Hydrolysis results in gelling and … Gelatin
Products Gliptins are commercially available in the form of film-coated tablets. Sitagliptin (Januvia) was the first representative to be approved in the United States in 2006. Today, various active ingredients and combination products are commercially available (see below). They are also called dipeptidyl peptidase-4 inhibitors. Structure and properties Some gliptins have a proline-like structure because … Gliptine
Products Pantothenic acid (vitamin B5) is contained in numerous multivitamin preparations, for example, in the form of tablets, capsules, effervescent tablets and as syrups. It is contained in both medicinal products and dietary supplements. Pantothenic acid is a component of the vitamin B complex. Structure and properties Pantothenic acid (C9H17NO5, Mr = 219.2 g/mol) is … Pantothenic Acid
Products Glatiramer acetate is commercially available as a solution for injection (Copaxone). It has been approved in many countries since 2004. Generic products were registered in 2015. Structure and properties Glatiramer acetate is the acetate salt of a synthetic polypeptide of the four natural amino acids glutamic acid, alanine, tyrosine, and lysine. The average molecular … Glatiramer Acetate
Structure and properties Alanine (C3H7NO2, Mr = 89.1 g/mol) Effects ATC V06CA Indications Food supplementation In infusion solutions
Products Albiglutide was approved in many countries, in the EU, and in the United States in 2014 in the form of an injectable (Eperzan). Structure and properties Albiglutide is a GLP-1 dimer (fragment of 30 amino acids, 7-36) fused to the human protein albumin. The amino acid alanine at position 8 has been replaced by … Albiglutide
Products Porcine insulin was commercially available as an injectable (insulin hypurin porcine). It was available as rapid-acting insulin, isophane insulin, and mixed insulin. Porcine insulin is stored in a refrigerator. It should not be frozen or exposed to high heat. Insulin Hypurin Porcine was withdrawn from the market in many countries on October 31, 2015. … Porcine Insulin
Products Teduglutide is commercially available as a powder and solvent for solution for injection (Revestive, USA: Gattex). It was approved in the EU and US in 2012 and in many countries in 2016. Structure and properties Teduglutide is an analog of the human polypeptide glucagon-like peptide-2 (GLP-2), which is secreted by L cells in the … Teduglutide
Products Some preparations containing amino acids are approved as medicinal products. These include, for example, methionine tablets or infusion preparations for parenteral nutrition. Amino acids are also marketed as dietary supplements, such as lysine, arginine, glutamine, and cysteine tablets. Protein powders such as whey protein can also be counted as amino acid supplements. Amino acids … Amino Acids
Alanine is a nonessential proteinogenic amino acid that serves as a building block for the synthesis of proteins. It is a chiral compound, and only the L form can be incorporated into proteins. In this context, alanine acts as a link between amino acid and carbohydrate metabolism. What is alanine? Alanine represents a proteinogenic amino … Alanine: Function & Diseases
