What is albumin? Albumin is a protein. It makes up around 60 percent of the total protein in blood serum. It is mainly produced in the liver cells (hepatocytes). Albumin serves, among other things, to buffer the pH value and as a readily available source of energy. However, it also has other important functions: Albumin … Albumin: What Your Lab Value Means
Products Infusion is the administration of a larger volume of fluid, usually intravenously into the blood, but also directly into organs or tissues. This is in contrast to injections, in which only small volumes are injected. The pharmacopoeia places special requirements on infusion preparations and the corresponding containers. Among other things, they must be germ-free, … Infusions
Hypalbuminemia is the name given to a form of hypoproteinemia. This is when there is too little albumin in the blood. Albumin is a plasma protein that is responsible for transporting many small-particle molecules. A deficiency of this protein can therefore cause various disorders such as the formation of edema and low blood pressure. What … Hypalbuminemia: Causes, Symptoms & Treatment
Products The first agent in the GLP-1 receptor agonist group to be approved was exenatide (Byetta) in the United States in 2005 and in many countries and the EU in 2006. In the meantime, several other drugs have been registered (see below). These drugs are also known as incretin mimetics. They are commercially available as … GLP-1 Receptor Agonists
Products Liraglutide was approved in many countries in 2009 as a solution for injection in a prefilled pen (Victoza). In 2014, a fixed-dose combination with insulin degludec was released (Xultophy); see IDegLira. In 2016, Saxenda was registered for the treatment of overweight and obesity. Its related successor, semaglutide, unlike liraglutide, only needs to be injected … Liraglutide
The common hepatic artery is a branch of the coeliac trunk and origin of the gastroduodenal artery and the hepatic propria artery. Its function is thus to supply the greater and lesser curvature of the stomach, great reticulum, pancreas, liver, and gallbladder. What is the common hepatic artery? One of the blood vessels in the … Common Hepatic Artery: Structure, Function & Diseases
Products Insulin detemir is commercially available as an injectable (Levemir). It has been approved in many countries since 2003. Structure and properties Insulin detemir (C267H402O76N64S6, Mr = 5916.9 g/mol) has an identical primary sequence to human insulin except for the removed threonine at position B30 of the B chain and an added molecule of myristic … Insulin Detemir
Definition On the one hand, drugs contain the active ingredients that mediate the pharmacological effects. On the other hand, they consist of excipients, which are used for the production or to support and regulate the drug effect. Placebos, which consist only of excipients and contain no active ingredients, are an exception. Excipients can be of … Auxiliary Materials
Definition and properties When active pharmaceutical ingredients enter the bloodstream, they often bind to proteins, especially albumin, to a greater or lesser extent. This phenomenon is called protein binding, and it is reversible: drug + protein ⇌ drug-protein complex Protein binding is important, first, because only the free portion distributes to tissues and induces a … Protein Binding
Products Albiglutide was approved in many countries, in the EU, and in the United States in 2014 in the form of an injectable (Eperzan). Structure and properties Albiglutide is a GLP-1 dimer (fragment of 30 amino acids, 7-36) fused to the human protein albumin. The amino acid alanine at position 8 has been replaced by … Albiglutide
Products Human albumin is commercially available as an infusion solution for intravenous use. Structure and properties Human albumin is a monomeric protein with a heart-shaped structure that can be extracted from human plasma for the production of drugs. In the body, it is produced by the liver. The mature protein consists of 585 amino acids, … Albumin: Protein in the Blood
Products Albutrepenone acog alfa was approved in many countries and in the EU in 2016 as a powder and solvent for the preparation of a solution for injection for intravenous use (Idelvion). Structure and properties Albutrepenonacog alfa is a recombinant fusion protein consisting of recombinant blood clotting factor IX combined with recombinant albumin. It is … Albutrepenonacog Alfa
