Products Zoledronic acid is commercially available as an infusion preparation (Zometa, Aclasta, generics). It has been approved in many countries since 2000. Structure and properties Zoledronic acid (C5H10N2O7P2, Mr = 272.1 g/mol) is present in drugs as zoledronic acid monohydrate, a white crystalline powder that is sparingly soluble in water. It is an imidazole derivative … Zoledronic Acid
Products Bisphosphonates are commercially available in the form of film-coated tablets and as injection and infusion preparations. They are also combined fixed with vitamin D3. Their effects on bone were described in the 1960s. Etidronate was the first active ingredient to be approved (out of trade). Structure and properties Bisphosphonates contain a central carbon atom … Bisphosphonates Effects and Side Effects
Products Alendronate is commercially available in the form of weekly tablets (Fosamax, generic). It is also combined fixed with vitamin D (cholecalciferol) (Fosavance, generic) and has been approved in many countries since 1996. Structure and properties Sodium alendronate (C4H12NNaO7P2 – 3H2O, Mr = 325.1 g/mol) exists as a white crystalline powder that is soluble in … Alendronate
Products Romosozumab was approved for injection in the United States and EU in 2019 and in many countries in 2020 (Evenity). Structure and properties Romosozumab is a humanized Ig2 monoclonal antibody with a molecular mass of 149 kDa produced by biotechnological methods. Effects Romosozumab (ATC M05BX06) promotes bone formation and, to a lesser extent, additionally … Romosozumab
ExplanationDefinition Fosamax® is a drug for the treatment of osteoporosis (bone loss). It belongs to the group of bisphosphonates, which inhibit the activity of the body’s own osteoclasts (naturally occurring bone-degrading cells). Their bone-destroying influence is predominant in many women after menopause, which is why osteoporosis (bone loss) develops. The consequences of osteoporosis can be … Fosamax®
Dosage Fosamax® once a week 70 mg tablets are taken as described above and the name of the preparation indicates it is taken once a week. Alternatively, Fosamax® is also available in 10 mg tablets. In this dosage form, the tablets are taken once daily. Please follow the instructions for use. Side effects Only the … Dosage | Fosamax®
Price Since there is always talk about cost pressure in the health care system, we think it is important to know the prices of medicines (prices are exemplary and not recommendable): Fosamax® 70 mg tablets | 4 Tbl. (N1) | 51,01 € Fosamax® 70 mg tablets | 12 Tbl. (N1) | 124,04 € Fosamax® 10 … Price | Fosamax®
Symptoms In osteoporosis, bones become weak, porous, and brittle and undergo structural changes. Even minor stresses can lead to a fracture, especially of the vertebrae, femoral neck, and wrists. Fractures pose a risk to the elderly and can lead to pain, hospitalization, surgery and disability. In the worst cases, they are even life-threatening. Other possible … Osteoporosis Causes and Treatment
Alendronic acid is a drug that is used for the treatment of osteoporosis. The drug belongs to the group of bisphosphates, which are chemical compounds containing two attached phosphate groups. However, common medicines do not contain an acid as the name “alendronic acid” suggests, but rather its salt (monosodium salt. For this reason, the name … Alendronic acid
Contraindications Alendronic acid must not be taken in case of any hypersensitivity and after an allergic reaction to the main active ingredient or other ingredients of the medication. In addition, patients suffering from diseases of the oesophagus (e.g. oesophagitis or reflux oesophagitis) should urgently refrain from taking this medicine, as the clinical picture could worsen. … Contraindications | Alendronic acid
