Amitriptyline: Effects, Usage, Side Effects

How amitriptyline works Amitriptyline is a drug from the group of so-called tricyclic antidepressants. It has a mood-lifting, anxiolytic and calming effect. Amitriptyline also alleviates the intensity of pain caused by nerve pain (neuropathic pain) and reduces the frequency of chronic tension headaches and migraines. Amitriptyline exerts these effects by influencing the sensitive balance of … Amitriptyline: Effects, Usage, Side Effects

Prolongation of the QT Interval

Symptoms Drug-induced prolongation of the QT interval can rarely lead to severe arrhythmias. This is polymorphic ventricular tachycardia, known as torsade de pointes arrhythmia. It can be seen on the ECG as a wave-like structure. Due to the dysfunction, the heart cannot maintain blood pressure and can only pump insufficient blood and oxygen to the … Prolongation of the QT Interval

Anxiolytics

Products Anxiolytics are commercially available in the form of tablets, capsules, and injectable preparations, among others. Structure and properties Anxiolytics are a structurally heterogeneous group. However, the representatives can be divided into different classes. These include, for example, the benzodiazepines or the tricyclic antidepressants. Effects Anxiolytics have antianxiety (anxiolytic) properties. They usually have additional effects, … Anxiolytics

Tension Headache

Symptoms Sporadic, frequent, or chronic in onset: A bilateral pain originating in the forehead and extending along the sides of the head to the occipital bone at the back of the skull Pain quality: pulling, pressing, constricting, non-pulsating. Duration between 30 minutes and 7 days Mild to moderate pain, normal daily activities are possible Radiation … Tension Headache

Medication Overuse Headache

Symptoms Medication-overuse headache, depending on the preexisting symptoms, manifests, for example, like a tension headache as bilateral, pressing pain, or like a migraine, unilateral, pulsating, and accompanied by nausea, vomiting, and sensitivity to light and noise. The pain occurs chronically for at least 15 days of the month, every other day or daily. When the … Medication Overuse Headache

Nortriptyline

Products Nortriptyline was commercially available in the form of film-coated tablets (nortrilen). It was approved in many countries in 1964. It was discontinued from distribution in 2016. Structure and properties Nortriptyline (C19H21N, Mr = 263.4 g/mol) is present in drugs as nortriptyline hydrochloride, a white powder that is sparingly soluble in water. It is an … Nortriptyline

Tricyclic Antidepressants

Products Tricyclic antidepressants are commercially available in many countries in the form of dragées, tablets, capsules, and drops. The first representative, imipramine, was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). Imipramine was approved in many countries in 1958. Structure … Tricyclic Antidepressants

Antidepressants

Products Most antidepressants are commercially available in the form of film-coated tablets. In addition, oral solutions (drops), meltable tablets, dispersible tablets, and injectables are also available, among others. The first representatives were developed in the 1950s. It was discovered that the antituberculosis drugs isoniazid and iproniazid (Marsilid, Roche) had antidepressant properties. Both agents are MAO … Antidepressants

Chloral Hydrate

Products Chloral hydrate was approved in many countries in 1954 and is commercially available as a solution (Nervifene). Other products such as Medianox and chloraldurate are no longer available. Structure and properties Chloral hydrate (C2H3Cl3O2, Mr = 165.4 g/mol) is in the form of colorless, transparent crystals that are very soluble in water. It has … Chloral Hydrate

Fibromyalgia Causes and Treatment

Symptoms Fibromyalgia is a chronic, noninflammatory disorder that manifests as pain throughout the body and is characterized by numerous other complaints. It is much more common in women than in men and usually first appears in middle age. Chronic, bilateral, diffuse pain. Muscle pain, pain in the limbs, back pain, joint pain, neck pain, headaches, … Fibromyalgia Causes and Treatment

Irritable Bowel Syndrome Causes and Treatment

Symptoms Irritable bowel syndrome is a functional bowel disorder that manifests itself in the following persistent or recurrent symptoms: Lower abdominal pain or cramping Diarrhea and/or constipation Flatulence Change in bowel habits, impaired defecation. Incontinence, urge to defecate, feeling of incomplete emptying. The symptoms improve with defecation. Some patients suffer mainly from diarrhea, others from … Irritable Bowel Syndrome Causes and Treatment