Prolongation of the QT Interval

Symptoms Drug-induced prolongation of the QT interval can rarely lead to severe arrhythmias. This is polymorphic ventricular tachycardia, known as torsade de pointes arrhythmia. It can be seen on the ECG as a wave-like structure. Due to the dysfunction, the heart cannot maintain blood pressure and can only pump insufficient blood and oxygen to the … Prolongation of the QT Interval

Enantiomers

Introductory question How much active ingredient is in a 10 mg cetirizine tablet? (a) 5 mg B) 7.5 mg C) 10 mg The correct answer is a. Image and mirror image Many active pharmaceutical ingredients exist as racemates. They consist of two molecules that behave like an image and mirror image of each other. These … Enantiomers

Antidepressants

Products Most antidepressants are commercially available in the form of film-coated tablets. In addition, oral solutions (drops), meltable tablets, dispersible tablets, and injectables are also available, among others. The first representatives were developed in the 1950s. It was discovered that the antituberculosis drugs isoniazid and iproniazid (Marsilid, Roche) had antidepressant properties. Both agents are MAO … Antidepressants

Escitalopram: Effects, Uses & Risks

Escitalopram is a drug that belongs to the group of selective serotonin reuptake inhibitors (SSRIs). It is used primarily in the treatment of depression. What is escitalopram? Escitalopram is an antidepressant that belongs to the group of selective serotonin reuptake inhibitors (SSRIs). It is used in the treatment of depression, generalized anxiety disorder, social phobias, … Escitalopram: Effects, Uses & Risks

Escitalopram

Products Escitalopram is commercially available as film-coated tablets, drops, and meltable tablets (Cipralex, generic). It has been approved in many countries since 2001. Structure and properties Escitalopram (C20H21FN2O, Mr = 324.4 g/mol) is the active -enantiomer of citalopram. It is present in drugs as escitalopram oxalate, a fine, white to slightly yellowish powder that is … Escitalopram

Citalopram Effects and Side Effects

Products Citalopram is commercially available as film-coated tablets and as an infusion concentrate (Seropram, generics). It has been approved in many countries since 1990. The pure -enantiomer escitalopram is also available (Cipralex, generic). Structure and properties Citalopram (C20H21FN2O, Mr = 324.4 g/mol) is a racemate. It is present in the tablets as citalopram hydrobromide, a … Citalopram Effects and Side Effects

Pharmaceutical Active Ingredient

Definition Active ingredients are the active components of a drug that are responsible for its pharmacological effects. Drugs may contain a single active ingredient, multiple active ingredients, or complex mixtures such as herbal extracts. In addition to the active ingredients, a drug contains various excipients that should be as pharmacologically inert as possible. The percentage … Pharmaceutical Active Ingredient

Generic

New drugs are protected Newly introduced drugs are usually protected by patent. Another company is not allowed to copy these drugs and distribute them themselves without the manufacturer’s consent. However, this protection expires after a few years. For example, the antidepressant escitalopram (Cipralex) was approved in many countries in 2001 and the patent protection was … Generic

Pimozide: Effects, Uses & Risks

The drug pimozide is an active substance that belongs to the category of so-called antipsychotics. The drug is primarily available on the pharmaceutical market under the trade name Orap. In the majority of cases, the drug pimozide is used orally in the form of tablets. In this context, the drug is used primarily for the … Pimozide: Effects, Uses & Risks