Products COX-2 inhibitors (coxibe) are commercially available in the form of film-coated tablets and capsules. The first representatives from this group to be approved in many countries were celecoxib (Celebrex, USA: 1998) and rofecoxib (Vioxx, off label) in 1999. At that time, they rapidly developed into blockbuster drugs. However, due to adverse effects, several drugs … COX-2 Inhibitor
Symptoms Gout is an inflammatory disease of the joints that manifests acutely in attacks of severe pain that worsens with pressure, touch, and movement. The joints are swollen with inflammation, and the skin is red and warm. Fever is observed. Gout often begins in the lower extremities and at the metatarsophalangeal joint (podagra). Urat crystals … Gout Causes and Treatment
Drug gastric protection Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for acute and long-term treatment of painful and inflammatory conditions. Active ingredients used include, for example, diclofenac, acetylsalicylic acid, ibuprofen, naproxen, and mefenamic acid. However, their use is limited by adverse effects that affect the upper digestive tract and are due to inhibition of prostaglandin … Stomach Protection
Products Nonsteroidal anti-inflammatory drugs (NSAIDs) are available in numerous dosage forms. These include film-coated tablets, tablets, sustained-release tablets, oral suspensions, oral granules, suppositories, NSAID eye drops, lozenges, emulsifying gels, and creams (selection). The first active ingredient from this group was salicylic acid, which was used medicinally in the 19th century in the form of the … NSAID
Products Etoricoxib is commercially available in the form of film-coated tablets (Arcoxia). It has been approved in many countries since 2009. Generics were registered in 2020. Structure and properties Etoricoxib (C18H15ClN2O2S, Mr = 358.8 g/mol) has a similar V-shaped structure to other COX-2 inhibitors. It is a dipyridinyl derivative with a methylsulfonyl group. Effects Etoricoxib … Etoricoxib
Symptoms The most common symptoms include cramping or dull abdominal pain. In addition, numerous other symptoms may occur, such as headache, menstrual migraine, back pain, pain in the legs, loss of appetite, nausea and vomiting, diarrhea, weakness, dizziness, flushing of the skin, flushing, sleep disturbances, mood swings, depression, irritability, and nervousness. The symptoms first appear … Menstrual Cramps
By definition, start-up pain, or run-away pain, is joint pain that occurs in the early stages of a movement, such as when running away from standing or when standing up after sitting for a long time. As the physical activity progresses, the pain then usually improves. Start-up pain is a so-called leading symptom for degenerative … Start-up Pain: Causes, Treatment & Help
As a COX-2 inhibitor, etoricoxib belongs to the non-steroidal anti-inflammatory drugs (NSAIDs). The active ingredient, which is used particularly as an anti-inflammatory and pain reliever, is thought to have properties that are gentler on the stomach and intestines than traditional nonsteroidal anti-inflammatory drugs. What is etoricoxib? Etoricoxib is generally applied in tablet form. Etoricoxib (molecular … Etoricoxib: Effects, Uses & Risks
Arcoxia 90mg in pregnancy Arcoxia® 90 and other active ingredients that inhibit cyclooxygenase 2 should not be taken by women who are trying to become pregnant because the implantation of potential germ cells and their supply could be disrupted. Arcoxia® 90 should also not be used during pregnancy. Although there are no studies on the … Arcoxia 90mg in pregnancy | Arcoxia 90mg
Introduction The drug Arcoxia® with the active ingredient etoricoxib is a selective inhibitor of the enzyme cyclooxygenase 2, which belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). Cyclooxygenase is involved in many metabolic processes in the body. Cyclooxygenase 2 alone occurs in some tissues and organs. Cyclooxygenase mediates an increase in fever through macrophages. … Arcoxia 90mg
Dosage Arcoxia® is not a medicine to be taken in children or adolescents or during pregnancy and lactation. Therapy with Arcoxia® can only be started at the age of 16 years. It is important that the drug is not overdosed. For pain therapy only such a low dose should be taken that the pain is … Dosage | Arcoxia 90mg
