Fluoroquinolones are a subgroup of the so-called quinolones. They are used in medicine as antibiotics. At the same time, they belong to the gyrase inhibitors and differ from other substances of this type by their wide spectrum of activity. Modern fluoroquinolones are effective against pathogen enzymes, such as topoisomerase IV, among others. What are fluoroquinolones? … Fluoroquinolones: Effect, Uses & Risks
Products The first active ingredient in the quinolone group to be introduced was nalidixic acid in 1967 (NegGram). It is no longer commercially available in many countries. Other drugs are available today (see below). Various dosage forms are available, for example, film-coated tablets, oral suspensions, eye drops, ear drops, and infusion solutions. Due to adverse … Quinolone
Products Temafloxacin (Omniflox) was withdrawn from the market in 1992 a few months after its initial approval in the United States because of the potential for serious side effects. Structure and properties Temafloxacin (C21H18F3N3O3, Mr = 417.4 g/mol) structurally belongs to the fluoroquinolones. Effects Temafloxacin (ATC J01MA05) is bactericidal. Effects are due to inhibition of … Temafloxacin
Moxifloxacin is an antibiotic used primarily in the treatment of bacterial diseases of the respiratory tract. Moxifloxacin, like the antibiotics ciprofloxacin and levofloxacin, belongs to the group of drugs called fluoroquinolones, which are also known as gyrase inhibitors. Moxifloxacin can be taken orally in the form of tablets or applied locally to the conjunctiva of … Moxifloxacin: Antibiotic for Bacterial Infections
Products Levofloxacin is commercially available as film-coated tablets and as an infusion solution (Tavanic, generic). It was approved in many countries in 1998. Generics came on the market in 2011. In 2018, a solution for a nebulizer was registered (Quinsair). The racemate ofloxacin is available as tablets (Tarivid), eye drops, and eye ointment (Floxal). Structure … Levofloxacin
Products Delafloxacin was approved in the United States in 2017, in the EU in 2019, and in many countries in 2020 as a powder for a concentrate for solution for infusion and in tablet form (Quofenix). Structure and properties Delafloxacin (C18H12ClF3N4O4, Mr = 440.8 g/mol) belongs to the group of fluoroquinolones. It is present in … Delafloxacin
Alternatives to fluoroquinolones Alternatives to fluoroquinolones are usually offered by other antibiotics. For example, antibiotic agents such as penicillins and cephalosporins are often used to treat bacterial infections. An exact effectiveness of the various substances can be seen from the antibiogram.In this process, bacteria extracted from the body are cultured in a so-called culture, after … Alternatives to fluoroquinolones | Fluoroquinolones
Introduction Fluoroquinolones are a group of antibiotics that are particularly suitable for the treatment of so-called Gram-negative rod bacteria. Rod bacteria are all types of bacteria that look rather elongated under the microscope. Gram-negative refers to a characteristic that is revealed by a special staining method (Gram-staining). Gram-negative rods are mostly bacteria that occur in … Fluoroquinolones
Side effect Like all antibiotics, fluoroquinolones cause side effects, mainly due to their desired effect (killing bacteria). Treatment with fluoroquinolones not only kills the disease-causing bacteria, but also the bacteria in the digestive tract and on the skin that naturally occur in the body can be inhibited and killed by fluoroquinolones. As a result, there … Side effect | Fluoroquinolones
Contraindications – When must not be given? Fluoroquinolones must not be given if there are allergies or intolerances to the active ingredient or other substances contained in the drug. Even in the case of severe side effects after fluoroquinolone therapy, renewed treatment with fluoroquinolones should be avoided. For example, anyone who has experienced central nervous … Contraindications – When must not be given? | Fluoroquinolones
Introduction Pneumonia is almost always caused by a bacterial infection. The pathogens are transmitted by coughing or sneezing and cause an inflammation of the lower respiratory tract. The most common triggers include pneumococcus in adults, and bacteria of the genus Haemophilus influenzae type b and Staphylococcus aureus in small children. Bacterial pneumonia is usually treated … Antibiotics for pneumonia
Which antibiotic is the best? In the case of pneumonia, the drug of choice is an antibiotic from the group of aminopenicillins (e.g. amoxicillin). However, which antibiotic works best in pneumonia depends on the patient’s age and concomitant diseases, his nicotine and alcohol consumption and the severity and cause of the infection. The most suitable … Which antibiotic is the best? | Antibiotics for pneumonia
